Journal ArticleDOI
High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults
TLDR
Higher ferritin and lower TSAT are associated with higher risk of preDM in a general population without confounding diseases.About:
This article is published in Clinical Nutrition.The article was published on 2013-12-01. It has received 47 citations till now. The article focuses on the topics: Transferrin saturation & Ferritin.read more
Citations
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Journal ArticleDOI
Iron and liver fibrosis: Mechanistic and clinical aspects.
TL;DR: The role of iron is described in various clinical pathologies, the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis are highlighted and the underlying mechanisms by which excess iron can facilitate fibrotic responses are examined.
Journal ArticleDOI
High prevalence of iron deficiency in patients with acute decompensated heart failure
Alain Cohen-Solal,Thibaud Damy,Mohamed Terbah,Sebastien Kerebel,Jean Philippe Baguet,Olivier Hanon,Faiez Zannad,Thierry Laperche,Christophe Leclercq,Victor Concas,Ladan Duvillié,Bernadette Darné,Stefan D. Anker,Alexandre Mebazaa +13 more
TL;DR: It is necessary to select patients suitable for decompensation of chronic heart failure for iron parameters based on prior history and once they are admitted to hospital, the iron levels in their blood are controlled for.
Journal ArticleDOI
Relationships of Serum Ferritin, Transferrin Saturation, and HFE Mutations and Self-Reported Diabetes Mellitus in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.
Ronald T. Acton,James C. Barton,Leah Passmore,Paul C. Adams,Mark Speechley,Fitzroy W. Dawkins,Phyliss Sholinsky,David M. Reboussin,Gordon D. McLaren,Gordon D. McLaren,Emily L. Harris,Thomas C. Bent,Thomas M. Vogt,Oswaldo Castro +13 more
TL;DR: Serum ferritin concentration is associated with diabetes, even at levels below those typically associated with hemochromatosis or iron overload.
Journal ArticleDOI
Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.
Clara Podmore,Karina Meidtner,Matthias B. Schulze,Robert A. Scott,Anna Ramond,Adam S. Butterworth,Emanuele Di Angelantonio,John Danesh,Larraitz Arriola,Aurelio Barricarte,Heiner Boeing,Françloise Clavel-Chapelon,Amanda J. Cross,Christina C. Dahm,Guy Fagherazzi,Paul W. Franks,Diana Gavrila,Sara Grioni,Marc J. Gunter,Gaëlle Gusto,Paula Jakszyn,Verena Katzke,Timothy J. Key,Tilman Kühn,Amalia Mattiello,Peter M. Nilsson,Anja Olsen,Kim Overvad,Domenico Palli,J. Ramón Quirós,Olov Rolandsson,Carlotta Sacerdote,Emilio Sánchez-Cantalejo,Nadia Slimani,Ivonne Sluijs,Annemieke M.W. Spijkerman,Anne Tjønneland,Rosario Tumino,Daphne L. van der A,Yvonne T. van der Schouw,Edith J. M. Feskens,Nita G. Forouhi,Stephen J. Sharp,Elio Riboli,Claudia Langenberg,Nicholas J. Wareham +45 more
TL;DR: The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2d is more complex than the simple link suggested by the association of ferritin with T1D.
Journal ArticleDOI
Biomarkers of iron metabolism are independently associated with impaired glucose metabolism and type 2 diabetes: the KORA F4 study
Cornelia Huth,Simon Beuerle,Astrid Zierer,Margit Heier,Christian Herder,Thorsten Kaiser,Wolfgang Koenig,Florian Kronenberg,Konrad Oexle,Wolfgang Rathmann,Michael Roden,Sigrid Schwab,Jochen Seissler,Doris Stöckl,Christa Meisinger,Annette Peters,Barbara Thorand +16 more
TL;DR: The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM.
References
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Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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Prevalence of Chronic Kidney Disease in the United States
Josef Coresh,Elizabeth Selvin,Lesley A. Stevens,Jane Manzi,John W. Kusek,Paul W. Eggers,Frederick Van Lente,Andrew S. Levey +7 more
TL;DR: The prevalence of CKD in the United States in 1999-2004 is higher than it was in 1988-1994 and this increase is partly explained by the increasing prevalence of diabetes and hypertension and raises concerns about future increased incidence of kidney failure and other complications.
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Use and Abuse of HOMA Modeling
TL;DR: The HOMA model has become a widely used clinical and epidemiological tool and, when used appropriately, it can yield valuable data, however, as with all models, the primary input data needs to be robust, and the data need to be interpreted carefully.