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High prevalence of headaches in patients with epilepsy

TLDR
The high prevalence of postictal headaches confirms the frequent triggering of a headache by a seizure, a condition in which the real triggering effect of the headache on the seizure might be difficult to prove.
Abstract
To examine the association between headaches and epilepsy. Consecutive adult epileptic patients who went to the outpatient clinic of the Epilepsy Center of PLA General Hospital between February 01, 2012, and May 10, 2013, were recruited into this study. A total of 1109 patients with epilepsy completed a questionnaire regarding headaches. Overall, 60.1% of the patients (male: 57.2%; female: 63.8%) reported headaches within the last year. The age-weighted prevalence of interictal migraine was 11.7% (male 8.9%, female 15.3%), which is higher than that reported in a large population-based study (8.5%, male 5.4%, female 11.6%) using the same screening questions. The prevalence of postictal headaches was 34.1% (males 32.7%, females 35.2%), and the presence of preictal headaches was 4.5% (males 4.3%, females 5.2%). The prevalence of headache yesterday in the general population was 4.8% (male 3.0%, female 6.6%). Thus, the prevalence of headaches, including migraine, is higher in epileptic patients in China. The high prevalence of postictal headaches confirms the frequent triggering of a headache by a seizure. A much lower frequency of preictal headaches, a condition in which the real triggering effect of the headache on the seizure might be difficult to prove.

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Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

TL;DR: This study examined which 5-HT receptor subtypes can be targeted to trigger antiseizure effects in homozygous scn1Lab(-/-) mutant zebrafish larvae that recapitulate DS well and confirmed the efficacy of fenfluramine as an antiepileptiform compound in zebra fish models of DS.
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Pathophysiological Bases of Comorbidity in Migraine.

TL;DR: In this paper, the authors proposed a multidisciplinary approach to identify and eliminate possible risk and comorbidity factors for the treatment of migraine, which is designed to maintain brain homeostasis by regulating homeostatic needs such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response.
Journal ArticleDOI

Epilepsy and headaches: Further evidence of a link

TL;DR: It is suggested that headaches, particularly migraine-type headaches, were frequently experienced by patients with epilepsy, postictal headaches were more common, and the frequency of migraine attacks could be linked with seizure frequency and the type of treatment.
Journal ArticleDOI

Prodrome in epilepsy.

TL;DR: Prodromes are characterized by a broad spectrum of preictal symptoms that may be experienced for a duration of between 10min and several days, which usually persist until seizure onset, and usually persist for between 30min and 24h.
References
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Journal ArticleDOI

Spreading depression and the clinical correlates of migraine.

TL;DR: Current data show that transgenic mice expressing familial hemiplegic migraine type 1 mutations in voltage-gated Ca2+ channels develop mutation-specific aura-like signs after a cortical SD similar to patients with the respective mutation, and these signs are associated with facilitated subcortical SD propagation.
Journal ArticleDOI

Clinical factors associated with post-ictal headache in patients with epilepsy.

TL;DR: The occurrence of PIH may be related to the area of epileptic focus and the region of spread of epilepsyptic discharges and younger age at onset of epilepsy was a risk factor for PIH.
Journal ArticleDOI

Cortical excitability in migraine and epilepsy: a common feature?

TL;DR: Cortical excitability increases in migraine suggesting the involvement of intracortical inhibitory circuits may be a common feature underlying some of the similarities observed in migraine and epilepsy.
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