High vs Low Frequency Neural Oscillations in Schizophrenia
Lauren V. Moran,L. Elliot Hong +1 more
TLDR
It is conceptualized that even isolated alterations in gamma or low frequency oscillations may impact the interactions of high and low frequency bands that are involved in key cognitive functions and may be critical for deciphering the complex electrophysiological abnormalities observed in schizophrenia patients.Abstract:
There is growing recognition that neural oscillations are important in a wide range of perceptual and cognitive functions. One of the key issues in electrophysiological studies of schizophrenia is whether high or low frequency oscillations, or both, are related to schizophrenia because many brain functions are modulated with frequency specificities. Many recent electrophysiological studies of schizophrenia have focused on high frequency oscillations at gamma band and in general support gamma band dysfunction in schizophrenia. We discuss the concept that gamma oscillation abnormalities in schizophrenia often occur in the background of oscillation abnormalities of lower frequencies. The review discusses the basic neurobiology for the emergence of oscillations of all frequency bands in association with networks of inhibitory interneurons and the convergence and divergence of such mechanisms in generating high vs low frequency oscillations. We then review the literature of oscillatory frequency abnormalities identified in each frequency band in schizophrenia. By describing some of the key functional roles exerted by gamma, low frequencies, and their cross-frequency coupling, we conceptualize that even isolated alterations in gamma or low frequency oscillations may impact the interactions of high and low frequency bands that are involved in key cognitive functions. The review concludes that studying the full spectrum and the interaction of gamma and low frequency oscillations may be critical for deciphering the complex electrophysiological abnormalities observed in schizophrenia patients.read more
Citations
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Journal ArticleDOI
Untangling cross-frequency coupling in neuroscience
Juhan Aru,Jaan Aru,Viola Priesemann,Michael Wibral,Luiz Lana,Gordon Pipa,Wolf Singer,Raul Vicente +7 more
TL;DR: This work organizes the available and potential novel statistical/modeling approaches according to their biophysical interpretability of cross-frequency coupling to provide a road map towards an improved mechanistic understanding of CFC.
Journal ArticleDOI
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.
Ruoqi Gao,Peter Penzes +1 more
TL;DR: Key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis are reviewed.
Journal ArticleDOI
Hierarchical organization of gamma and theta oscillatory dynamics in schizophrenia.
TL;DR: Results suggest that schizophrenia patients have specific alterations in both gamma and theta oscillations, but these deficits occur in the context of an intact hierarchical organization of their cross-frequency modulation in response to 40-Hz steady-state stimulation.
Journal ArticleDOI
Altered Cortical Ensembles in Mouse Models of Schizophrenia
TL;DR: Results are consistent with the hypothesis that schizophrenia is an "attractor" disease and demonstrate that degraded neuronal ensembles are a common consequence of diverse genetic, cellular, and synaptic alterations seen in chronic schizophrenia.
Journal ArticleDOI
Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia
Keizo Takao,Katsunori Kobayashi,Hideo Hagihara,Koji Ohira,Hirotaka Shoji,Satoko Hattori,Hisatsugu Koshimizu,Juzoh Umemori,Keiko Toyama,Hironori K. Nakamura,Mahomi Kuroiwa,Jun Maeda,Kimie Atsuzawa,Kayoko Esaki,Shun Yamaguchi,Shigeki Furuya,Tsuyoshi Takagi,Noah M. Walton,Nobuhiro Hayashi,Hidenori Suzuki,Makoto Higuchi,Nobuteru Usuda,Tetsuya Suhara,Akinori Nishi,Mitsuyuki Matsumoto,Shunsuke Ishii,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa +27 more
TL;DR: It is shown that Shn-2 KO mice have behavioral abnormalities that resemble those of schizophrenics, and genetically induced changes in immune system can be a predisposing factor in schizophrenia.
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