Journal ArticleDOI
Highly improved adsorption selectivity of L-phenylalanine imprinted polymeric submicron/nanoscale beads prepared by modified suspension polymerization
TLDR
In this article, the effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied.Abstract:
Molecularly imprinted polymer (MIP) submicron/nanoscale beads selective for L-Phenylalanine (L-Phe) and D-Phe as well as non-imprinted beads were prepared by modified suspension polymerization involving agitation of the reaction mixture at high rotation speed under safe radical conditions. The effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied. L-Phe-imprinted submicron/nanoscale beads prepared for the first time by modified suspension polymer- ization showed enhanced adsorption capacity and selectivity over those of D-Phe imprinted and non-imprinted beads. Maximum adsorption capacity, 0.35 mg/g, and selectivity, 1.62, of L-Phe imprinted submicron/nanoscale beads were higher than the adsorption capacities, 0.30 and 0.19 mg/g, and selectivities, 1.59 and 1.02, of D-Phe imprinted and non- imprinted submicron/nanoscale beads, respectively. FE-SEM analyses revealed that L- and D-Phe imprinted beads were larger (100 nm-1.5 µm) than non-imprinted nanobeads (100-800 nm). 13 C CP-MAS NMR spectroscopy helped in cor- relating the bead sizes and the extent of reaction during polymerization. Similarly, FT-IR study was used for evaluation of structural characteristics of the prepared Phe-imprinted and non-imprinted beads. The preparation of Phe-imprinted submicron/nanoscale beads with improved adsorption and separation properties and the study of effect of template on the size and performance of the prepared beads are suitable from both economical and research point of view in MIP field.read more
Citations
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Journal ArticleDOI
Fabrication of magnetic core shell particles coated with phenylalanine imprinted polymer
Saba Gul,Nasrullah Shah,Muhammad Balal Arain,Nida Rahman,Touseef Rehan,Mazhar Ul-Islam,Muhammad Wajid Ullah,Guang Yang +7 more
TL;DR: In this article, magnetic iron oxide nanoparticles with excellent magnetic behavior were synthesized by co-precipitation method followed by their surface modification to obtain Fe3O4@SiO2 NH2 and polymerization to fabricate d -phenylalanine (D-Phe) imprinted magnetic core-shell polymer (PIMP) and non-imprinted magnetic core shell polymer (NIMP).
Journal ArticleDOI
Synthesis of a phenylalanine imprinted polymer for attenuation of phenylalanine absorption via the gut in a murine hyperphenylalaninemia model
Parvaneh Najafizadeh,Soltan Ahmad Ebrahimi,Mohammad Reza Panjeshahin,Kambiz Kamyab Hesari,Seyed Mahdi Rezayat Sorkhabadi +4 more
TL;DR: It is suggested that the MIP against Phe can decrease the blood Phe concentration in an animal model of hyperphenylalaninemia, a genetic disease characterized by accumulation of phenylalanine in blood with toxic consequences.
Journal ArticleDOI
Adsorptive molecularly imprinted composite membranes for chiral separation of phenylalanine
TL;DR: In this paper, two types of composite imprinted membranes, i.e., composite membrane comprised of D-Phe imprinted beads and D -Phe- imprinted membrane or DCM, and composite membrane comprising of L-phe imprinting beads and L- phe-imprinted membranes or LCM, were synthesized by phase inversion technique after a uniform dispersion of beads within the polymeric solutions using simple physico-mechanical process.
Journal ArticleDOI
Core-Shell Molecularly Imprinted Polymer Nanocomposites for Biomedical and Environmental Applications.
TL;DR: This review covers the approaches of developing the CSMIPs synthetic schemes, and their application with special emphasis on uses in the biomedical field, food care subjects, plant extracts analysis and in environmental studies.
Journal ArticleDOI
Preparation and recognition characteristics of alanine surface molecularly imprinted polymers
TL;DR: In this article, surface molecularly imprinted polymers (SMIPs) with high performance in selectively recognizing alanine (Ala) were prepared using a facile surface molecular-imprinting technique.
References
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Journal ArticleDOI
A surface functional monomer-directing strategy for highly dense imprinting of TNT at surface of silica nanoparticles.
TL;DR: A critical value of shell thickness for the maximum rebindingcapacity was determined by testing the evolution of rebinding capacity with shell thickness, which provides new insights into the effectiveness of molecular imprinting and the form of imprinted materials.
Journal ArticleDOI
Molecularly imprinted polymer beads : Suspension polymerization using a liquid perfluorocarbon as the dispersing phase
Andrew G. Mayes,Klaus Mosbach +1 more
TL;DR: A suspension polymerization technique suitable for molecular imprinting is described, based on the use of a liquid perfluorocarbon as the dispersing phase, which produces polymer beads, with almost quantitative yield, which can be used after only a simple washing step.
Journal ArticleDOI
Uniform molecularly imprinted microspheres and nanoparticles prepared by precipitation polymerization: the control of particle size suitable for different analytical applications.
TL;DR: New synthetic conditions are initiated to obtain MIP beads with controllable size in the nano- to micro-meter range, using racemic propranolol as a model template, and the imprinted sites displayed high chiral selectivity.
Journal ArticleDOI
Molecular imprinting at walls of silica nanotubes for TNT recognition.
TL;DR: The silica nanotube reported herein is an ideal form of material for imprinting various organic or biological molecules toward applications in chemical/biological sensors and bioassay.