Journal ArticleDOI
Highly improved adsorption selectivity of L-phenylalanine imprinted polymeric submicron/nanoscale beads prepared by modified suspension polymerization
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TLDR
In this article, the effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied.Abstract:
Molecularly imprinted polymer (MIP) submicron/nanoscale beads selective for L-Phenylalanine (L-Phe) and D-Phe as well as non-imprinted beads were prepared by modified suspension polymerization involving agitation of the reaction mixture at high rotation speed under safe radical conditions. The effects of pH, template and concentration of racemate solution on the performance of the phenylalanine (Phe) imprinted polymeric submicron/nanoscale beads were studied. L-Phe-imprinted submicron/nanoscale beads prepared for the first time by modified suspension polymer- ization showed enhanced adsorption capacity and selectivity over those of D-Phe imprinted and non-imprinted beads. Maximum adsorption capacity, 0.35 mg/g, and selectivity, 1.62, of L-Phe imprinted submicron/nanoscale beads were higher than the adsorption capacities, 0.30 and 0.19 mg/g, and selectivities, 1.59 and 1.02, of D-Phe imprinted and non- imprinted submicron/nanoscale beads, respectively. FE-SEM analyses revealed that L- and D-Phe imprinted beads were larger (100 nm-1.5 µm) than non-imprinted nanobeads (100-800 nm). 13 C CP-MAS NMR spectroscopy helped in cor- relating the bead sizes and the extent of reaction during polymerization. Similarly, FT-IR study was used for evaluation of structural characteristics of the prepared Phe-imprinted and non-imprinted beads. The preparation of Phe-imprinted submicron/nanoscale beads with improved adsorption and separation properties and the study of effect of template on the size and performance of the prepared beads are suitable from both economical and research point of view in MIP field.read more
Citations
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Journal ArticleDOI
Molecular imprinting science and technology: a survey of the literature for the years 2004-2011.
TL;DR: A survey of the literature covering the development of molecular imprinting science and technology over the years 2004–2011 and efforts to apply these polymeric materials to a range of application areas is presented.
Journal ArticleDOI
Recent applications of molecular imprinted polymers for enantio-selective recognition.
TL;DR: In this review, progresses in applications of enantio-selective recognition by MIPs will be critically reviewed for the recent period since 2007.
Journal ArticleDOI
Preparation of molecularly imprinted polymers using theanine as dummy template and its application as SPE sorbent for the determination of eighteen amino acids in tobacco
TL;DR: A novel dummy template molecularly imprinted polymer (DMIP) based on a vinyl-SiO2 microspheres surface for the simultaneous selective recognition and enrichment of 18 amino acids was prepared via a surface molecular imprinting technique using theanine as a dummy template, indicating that the obtained DMIP sorbents have high selectivity.
Journal ArticleDOI
Designing and controlling the morphology of spherical molecularly imprinted polymers
TL;DR: In this article, a critical review of morphology design and control of spherical molecular imprinted polymers (MIPs) is presented, focusing on solid sphere, core-shell, hollow and mesoporous MIPs.
References
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Journal ArticleDOI
Surface molecularly imprinted nanowires for biorecognition.
TL;DR: A novel method for preparation of surface molecularly imprinted size-monodisperse nanowires that can be dissolved in aqueous media and likely suited for imprinting and recognition of large-molecular-weight peptides and proteins.
Journal ArticleDOI
Evaluation of methods aimed at complete removal of template from molecularly imprinted polymers
Arndt Ellwanger,Christine Berggren,Sami Bayoudh,Carlo Crecenzi,Lars Karlsson,Paul K. Owens,Kees Ensing,Peter A. G. Cormack,David C. Sherrington,Börje Sellergren +9 more
TL;DR: Polymers imprinted with clenbuterol were used to study the influence of various post-polymerization treatments on the bleeding of residual template, and a milder but still efficient method to reduce the bleeding level was found to be MAE with formic acid.
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Molecularly imprinted polymer nanospheres as synthetic affinity receptors obtained by miniemulsion polymerisation
TL;DR: In this paper, a chiral molecular template, L- or D-Boc-phenylalanine anilid, was used for the nano-emulsion polymerization of high-crosslinked polymer nanospheres composed of poly[methacrylic acid]-co-(ethylene glycol dimethacrylate)] and poly(EGDMA) and the resulting microgels were characterised by surface tension measurements, gravimetric analysis, dynamic light scattering, transmission electron microscopy, 1 H and 13 C CP-MAS NMR, and Brun
Journal ArticleDOI
Chemiluminescence imaging ELISA using an imprinted polymer as the recognition element instead of an antibody.
TL;DR: An imaging assay analogous to competitive enzyme immunoassays has been developed using a molecularly imprinted polymer instead of an antibody using the antigen 2,4-dichlorophenoxyacetic acid and the chemiluminescence reaction of luminol for detection.
Journal ArticleDOI
Catalytic Silica Particles via Template-Directed Molecular Imprinting
Michael A. Markowitz,Paul R. Kust,Gang Deng,Paul E. Schoen,Jonathan S. Dordick,and Douglas S. Clark,Bruce P. Gaber +6 more
TL;DR: In this article, the surfaces of silica particles were molecularly imprinted with an α-chymotrypsin transition-state analogue (TSA) by utilizing the technique of template-directed synthesis of mineralized materials.