Journal ArticleDOI
Highly Sensitive Detection of Bladder Cancer-Related miRNA in Urine Using Time-Gated Luminescent Biochip.
Yingqian Wang,Zhihao Li,Qiaosong Lin,Yurong Wei,Jie Wang,Yingxue Li,Ronghua Yang,Quan Yuan,Quan Yuan +8 more
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TLDR
An ultralow background biochip based on time-gated luminescent probes supported by photonic crystals (PCs) was successfully developed for detection of BC-related miRNA biomarkers with high sensitivity and specificity in urine samples.Citations
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Molecular Probes for Autofluorescence-Free Optical Imaging.
Yuyan Jiang,Kanyi Pu +1 more
TL;DR: In this paper, the authors focus on the advancements of autofluorescence-free molecular probes through the lens of particular molecular or photophysical mechanisms that produce long-lasting luminescence after the cessation of light excitation.
Journal ArticleDOI
Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications.
TL;DR: The works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs are summarized and the recent advances in biosensing, imaging and imaging-guided therapy are highlighted.
Journal ArticleDOI
Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing
TL;DR: The article covers the basic mechanism of MEF and recent developments in plasmonic nanostructures fabrication for efficient fluorescence signal enhancement that are critically reviewed, which are in practice to detect different analytes relevant to food control, medical diagnostics, and forensic science.
Journal ArticleDOI
Ultrasensitive Photoelectrochemical Detection of MicroRNA on Paper by Combining a Cascade Nanozyme-Engineered Biocatalytic Precipitation Reaction and Target-Triggerable DNA Motor
TL;DR: PEC sensor rationally designed for sensing microRNA based on simple self-assembly of target-triggerable DNA nanomotor and nanozymes-catalyzed multistage biocatalytic precipitation reaction is successfully performed and exhibits potential capability in detection of other targets.
Journal ArticleDOI
A boosting upconversion luminescent resonance energy transfer and biomimetic periodic chip integrated CRISPR/Cas12a biosensor for functional DNA regulated transduction of non-nucleic acid targets.
TL;DR: The analysis of real complex samples demonstrate that the as-proposed platform can work as a powerful toolbox for monitoring the ATP fluctuation in single cell and point-of-care testing Na+ in human plasma, enabling a broad application prospect.
References
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Journal ArticleDOI
A clearer vision for in vivo imaging.
TL;DR: Progress continues in the development of smaller, more penetrable probes for biological imaging, and the number of probes in this line of research has increased.
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
TL;DR: Although MRI, US, and x-ray CT are often listed as molecular imaging modalities, in truth, radionuclide and optical imaging are the most practical modalities for molecular imaging, because of their sensitivity and the specificity for target detection.
Journal ArticleDOI
High performance plasma amyloid-β biomarkers for Alzheimer’s disease
Akinori Nakamura,Naoki Kaneko,Victor L. Villemagne,Takashi Kato,James D. Doecke,Vincent Dore,Christopher Fowler,Qiao-Xin Li,Ralph N. Martins,Christopher C. Rowe,Taisuke Tomita,Katsumi Matsuzaki,Kenji Ishii,Kazunari Ishii,Yutaka Arahata,Shinichi Iwamoto,Kengo Ito,Koichi Tanaka,Colin L. Masters,Katsuhiko Yanagisawa +19 more
TL;DR: The measurement of high-performance plasma amyloid-β biomarkers by immunoprecipitation coupled with mass spectrometry demonstrates the potential clinical utility of plasma biomarkers in predicting brain amyloids-β burden at an individual level and shows cost–benefit and scalability advantages over current techniques.
Journal ArticleDOI
Long persistent phosphors—from fundamentals to applications
TL;DR: A review of the recent developments in LPPs for the synthesis of nanoparticles from the aspects of particle sizes, monodispersity and homogeneity based on the urgent application of bio-imaging, and an exhibition of new products towards diverse application fields.
Journal ArticleDOI
Identification of novel microRNA targets based on microRNA signatures in bladder cancer.
Takahiro Ichimi,Hideki Enokida,Yasushi Okuno,Ryo Kunimoto,Takeshi Chiyomaru,Ken Kawamoto,Kazuya Kawahara,Kazuki Toki,Kazumori Kawakami,Kenryu Nishiyama,Gozoh Tsujimoto,Masayuki Nakagawa,Naohiko Seki +12 more
TL;DR: The target search algorithm and gene‐expression profiling in BCs revealed that Keratin7 (KRT7) mRNA was a common target of the downregulated miRNAs, and the mRNA expression levels of KRT7 were significantly higher inBCs than in NBEs.