Human Alzheimer and Inflammation Biomarkers after Anesthesia and Surgery
Junxia X. Tang,Dimitry Baranov,Mary Hammond,Leslie M. Shaw,Maryellen F. Eckenhoff,Roderic G. Eckenhoff +5 more
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TLDR
A robust neuroinflammatory response was found in CSF biomarkers during surgery, largely because of an increase in total-tau rather than a decline in amyloid-&bgr;(1–42), which suggests that anesthetic management may make a difference in neuro inflammatory response.Abstract:
Background
The prevalence of post-operative cognitive disturbance, coupled with growing in vitro, cell and animal evidence suggesting anesthetic effects on neurodegeneration, calls for further study of the interaction between surgical care and Alzheimer neuropathology. Here, we study human cerebral spinal fluid (CSF) biomarkers perioperatively.read more
Citations
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Journal ArticleDOI
Lasting impact of general anaesthesia on the brain: mechanisms and relevance.
Laszlo Vutskits,Zhongcong Xie +1 more
TL;DR: Available mechanistic data linking general-anaesthesia exposure to impaired cognitive performance in both young and mature nervous systems are reviewed, providing a critical appraisal of the translational value of animal models.
Journal ArticleDOI
Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning
Iris B. Hovens,Regien G. Schoemaker,Eddy A. van der Zee,Anthony Absalom,Erik Heineman,Barbara L. van Leeuwen +5 more
TL;DR: The findings indicate that in young adult rats only spatial learning and memory is affected by surgery, suggesting hippocampal dependent cognition is especially vulnerable to surgery-induced impairment.
Journal ArticleDOI
Neuroinflammation and Perioperative Neurocognitive Disorders.
TL;DR: The role of postoperative neuroinflammation and underlying mechanisms in immune-to-brain signaling after peripheral surgery are reviewed.
Journal ArticleDOI
Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies.
David Skvarc,Michael Berk,Michael Berk,Linda K. Byrne,Olivia M Dean,Seetal Dodd,Matthew Lewis,Andrew Marriott,Eileen M. Moore,Gerwyn Morris,Richard S. Page,Laura J. Gray +11 more
TL;DR: This review aims to describe the putative mechanisms by which surgery‐induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.
Journal ArticleDOI
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.
Le Freche H,Jonathan Brouillette,Francisco-Jose Fernandez-Gomez,Patin P,Raphaëlle Caillierez,Nadège Zommer,Nicolas Sergeant,Buée-Scherrer,Gilles Lebuffe,David Blum,Luc Buée +10 more
TL;DR: It is demonstrated, in mice, that sevoflurane exposure is associated with increased tau phosphorylation through specific kinases activation and spatial memory deficits, which support a correlation between exposures to this anesthetic agent and cognitive decline.
References
More filters
Journal ArticleDOI
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Leslie M. Shaw,Hugo Vanderstichele,Malgorzata Knapik-Czajka,Christopher M. Clark,Paul S. Aisen,Ronald C. Petersen,Kaj Blennow,Holly Soares,Adam J. Simon,Piotr Lewczuk,Robert A. Dean,Eric Siemers,William Z. Potter,Virginia M.-Y. Lee,John Q. Trojanowski +14 more
TL;DR: Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects.
Journal ArticleDOI
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
John R. Cirrito,Kelvin A. Yamada,Mary Beth Finn,Robert S. Sloviter,Kelly R. Bales,Patrick C. May,Darryle D. Schoepp,Steven M. Paul,Steven Mennerick,David M. Holtzman +9 more
TL;DR: It is demonstrated that Aβ levels in the brain interstitial fluid are dynamically and directly influenced by synaptic activity on a timescale of minutes to hours, and it is suggested that synaptic activity may modulate a neurodegenerative disease process, in this case by influencing Aβ metabolism and ultimately region-specific Aβ deposition.
Journal ArticleDOI
Advanced multiplexed analysis with the FlowMetrixTM system
TL;DR: The FlowMetrix System is a multiplexed data acquisition and analysis platform for flow cytometric analysis of microsphere-based assays that performs simultaneous measurement of up to 64 different analytes.
Journal ArticleDOI
Role of interleukin-1beta in postoperative cognitive dysfunction.
Mario Cibelli,Antonio Rei Fidalgo,Niccolò Terrando,Niccolò Terrando,Daqing Ma,Claudia Monaco,Marc Feldmann,Masao Takata,Isobel J. Lever,Jagdeep Nanchahal,Michael S. Fanselow,Mervyn Maze,Mervyn Maze +12 more
TL;DR: Whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery is explored.
Journal ArticleDOI
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
John R. Cirrito,Jae Eun Kang,Jiyeon Lee,Floy R. Stewart,Deborah K. Verges,Luz M. Silverio,Guojun Bu,Steven Mennerick,David M. Holtzman +8 more
TL;DR: It is estimated that approximately 70% of ISF Abeta arises from endocytosis-associated mechanisms, with the vast majority of this pool also dependent on synaptic activity, which has implications for AD pathogenesis and may provide insights into therapeutic intervention.