Journal ArticleDOI
Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy
Seisuke Sayama,Takeshi Nagamatsu,Danny J. Schust,Naoko Itaoka,Mayuko Ichikawa,Kei Kawana,Takahiro Yamashita,Shiro Kozuma,Tomoyuki Fujii +8 more
TLDR
Functional assays demonstrated that DMs are able to suppress T cell IFN-γ production via B7-H1:PD-1 interactions, and may contribute to the development of appropriate maternal immune responses to the fetus in early pregnancy.About:
This article is published in Journal of Reproductive Immunology.The article was published on 2013-12-01. It has received 40 citations till now. The article focuses on the topics: T cell & Immune tolerance.read more
Citations
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Journal ArticleDOI
The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages
Judit Svensson-Arvelund,R.B. Mehta,Robert Lindau,Elahe Mirrasekhian,Heriberto Rodriguez-Martinez,Göran Berg,Gendie E. Lash,Maria C. Jenmalm,Jan Ernerudh +8 more
TL;DR: It is shown that the human fetal placenta itself, mainly through trophoblast cells, is able to induce homeostatic M2 macrophages and Tregs, and these findings have implications for immune-mediated pregnancy complications, as well as for general understanding of tissue-induced tolerance.
Journal ArticleDOI
Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment.
TL;DR: Development of the EVT lineage is summarized, a process occurring independently of the uterine environment, and formation of its different subtypes are discussed and it is suggested that the decidua and its different immune cells regulate EVT differentiation, invasion and survival.
Journal ArticleDOI
Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface.
TL;DR: Information from previous studies is summarized, which may lay the foundation for the diagnosis of pathological pregnancy and put forward new ideas for future studies about dynamic changes in immune cells in mid and late pregnancy.
Journal ArticleDOI
The role of decidual immune cells on human pregnancy.
TL;DR: How key immune cells contribute to pregnancy outcome and the complex interactions between the innate and adaptive immune system during human pregnancy are discussed.
Journal ArticleDOI
miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity
Long Jia,Qing Xi,Huafeng Wang,Zimu Zhang,Hongkun Liu,Yingnan Cheng,Xiangdong Guo,Jieyou Zhang,Qi Zhang,Lijuan Zhang,Zhenyi Xue,Yan Li,Yurong Da,Peng Zhao,Rongxin Zhang,Rongxin Zhang +15 more
TL;DR: Wang et al. as mentioned in this paper found that PD-L1 could be the target of miR142-5p by using bioinformatics methods, then they conduct luciferase activity assay, RT-PCR and western blot experiments to demonstrate that miR-142- 5p can regulate PDL1 expression by binding to its 3'UTR.
References
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
TL;DR: The results suggest that activation of the PD‐1 gene may be involved in the classical type of programmed cell death.
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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
TL;DR: It is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses in lymphocytes and monocytic cells following activation.
Journal ArticleDOI
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
Richard V. Parry,Jens M. Chemnitz,Kenneth A. Frauwirth,Anthony R. Lanfranco,Inbal Braunstein,Sumire V. Kobayashi,Peter S. Linsley,Craig B. Thompson,James L. Riley +8 more
TL;DR: In this paper, CTLA-4 and PD-1 signaling inhibited Akt phosphorylation by preventing CD3/CD28-mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms.
Journal ArticleDOI
Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy
TL;DR: Etude du controle de la proliferation des lymphocytes T par les cellules presentant l'antigene, examen des signaux biologiques and biochimiques impliques dans ce mecanisme.