Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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HPV16E7d candidate vaccine modified genes expression in tumor environment: flic as adjuvant changed tgf-b gene expression
TL;DR: Although these proteins are small, they have high capacity in binding to regulatory proteins of host cell to create malignancy in target tissues, it is believed that a bare protein is not enough immunogenic and should be formulated in adjuvants.
Journal ArticleDOI
The possible impact of novel mutations in human papillomavirus 52 on the infection characteristics
Yingxin Gong,Yan Wang,Qi Zhou,Wenjie Qu,Fang Chen,Yaping Wang,Jiayin Mo,Hongwei Zhang,Lin Lin,Long Sui,Yanyun Li +10 more
TL;DR: Wang et al. as mentioned in this paper found that 98.39% of the collected variants belonged to the sublineage B2 and two variants displayed incongruence between the phylogenetic tree of E6 and L1.
Risk factors and molecular predispositions for cervical dysplasia among women from east Croatia
Magdalena Perić,Zinka Bošnjak,Snježana Džijan,Dinko Paulić,Ivana Roksandić-Križan,Ivona Djurkin-Kušec,Maja Bogdan,Dubravka Vuković,Stjepan Rudan +8 more
TL;DR: This poster presents a probabilistic procedure to characterize the response of the immune system to various types of antibiotics and its applications in medicine and agriculture.
OtherDOI
Human Papillomavirus as a Risk Factor for Oropharyngeal Squamous Cell Carcinoma
TL;DR: The most significant risk factor for HPV-mediated oropharyngeal squamous cell carcinoma (OPSCC) is gender as mentioned in this paper , while lifestyle factors may also influence the persistence and oncogenic potential of the virus, thereby mediating the development of HPV-positive OPSCC.
Posted ContentDOI
Impact of HPV-16 lineages infection on response to radio-chemotherapy in cervical cancer
TL;DR: In this paper , the frequency of Human papilloma virus (HPV) 16 lineages in specimens of cervical cancer, relate the pathological factors in those variants and assess the response to treatment with radical chemoradiotherapy.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
Journal ArticleDOI
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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