Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Journal ArticleDOI
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
Zheng Hu,Da Zhu,Wei Wang,Weiyang Li,Wenlong Jia,Xi Zeng,Wencheng Ding,Lan Yu,Xiaoli Wang,Liming Wang,Hui Shen,Changlin Zhang,Hongjie Liu,Xiao Liu,Yi Zhao,Xiaodong Fang,Shuai Cheng Li,Wei Chen,Tang Tang,Aisi Fu,Zou Wang,Gang Chen,Qinglei Gao,Shuang Li,Ling Xi,Changyu Wang,Shujie Liao,Xiangyi Ma,Peng Wu,Kezhen Li,Shixuan Wang,Jianfeng Zhou,Wang Jun,Xun Xu,Hui Wang,Ding Ma +35 more
TL;DR: Microhomologous sequence between the human and HPV genomes was significantly enriched near integration breakpoints, indicating that fusion between viral and human DNA may have occurred by microhomology-mediated DNA repair pathways.
Journal ArticleDOI
The natural history of human papillomavirus infection.
TL;DR: Viral load and viral type are the main cofactors for progression from infection to cervical intraepithelial lesions and cancer and the adverse health effects of HPV infections can be largely controlled through vaccination and screening.
Journal ArticleDOI
HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis
Lisa Mirabello,Meredith Yeager,Kai Yu,Gary M. Clifford,Yanzi Xiao,Bin Zhu,Michael Cullen,Michael Cullen,Joseph Boland,Joseph Boland,Nicolas Wentzensen,Chase W. Nelson,Tina Raine-Bennett,Zigui Chen,Sara Bass,Sara Bass,Lei Song,Lei Song,Qi Yang,Qi Yang,Mia Steinberg,Mia Steinberg,Laurie Burdett,Laurie Burdett,Michael Dean,David Roberson,David Roberson,Jason Mitchell,Jason Mitchell,Thomas Lorey,Silvia Franceschi,Philip E. Castle,Joan L. Walker,Rosemary E. Zuna,Aimée R. Kreimer,Daniel C. Beachler,Allan Hildesheim,Paula Gonzalez,Carolina Porras,Robert D. Burk,Mark Schiffman +40 more
TL;DR: Strict conservation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic research.
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Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives
TL;DR: In spite of the successful implementation of the HPV vaccination program in many countries all over the world, problems related to HPV prevention and treatment of the related diseases will continue to persist in developing and underdeveloped countries.
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The precision prevention and therapy of HPV-related cervical cancer: new concepts and clinical implications.
TL;DR: The fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients.
References
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Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication.
TL;DR: A meta‐analysis of HPV type‐specific prevalence data published from 1990 to 2010 found that overall HPV prevalence increased significantly and the proportion of ICC associated with HPV16 and/or 18 (HPV16/18) was between 70 and 76% in all world regions except Asia.
Journal ArticleDOI
Human papillomavirus type 16 DNA sequence
TL;DR: The complete nucleotide sequence of HPV16 DNA cloned from an invasive cervical carcinoma was determined, and an interruption of the reading frame coding for a suspected E1 protein is revealed.
Journal ArticleDOI
Human papillomavirus types in 115,789 HPV‐positive women: A meta‐analysis from cervical infection to cancer
Peng Guan,Rebecca Howell-Jones,Rebecca Howell-Jones,Ni Li,Ni Li,Laia Bruni,Silvia de Sanjosé,Silvia Franceschi,Gary M. Clifford +8 more
TL;DR: Genotyping may improve risk stratification of high‐risk (HR) human papillomavirus (HPV)‐positive women in cervical screening programs; however, prospective data comparing the natural history and carcinogenic potential of individual HR types remain limited.
Journal ArticleDOI
The carcinogenicity of human papillomavirus types reflects viral evolution
Mark Schiffman,Rolando Herrero,Rob DeSalle,Allan Hildesheim,Sholom Wacholder,Ana Cecilia Rodriguez,M C Bratti,Mark E. Sherman,Jorge Morales,Diego Guillén,Mario Alfaro,Martha Hutchinson,Thomas C. Wright,Diane Solomon,Zigui Chen,John Schussler,Philip E. Castle,Robert D. Burk +17 more
TL;DR: HPV16 was uniquely likely both to persist and to cause neoplastic progression when it persisted, making it a remarkably powerful human carcinogen that merits separate clinical consideration, and several clear clues and research directions are presented in the ongoing efforts to understand HPV carcinogenesis.
Journal ArticleDOI
Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective.
TL;DR: Intatype human papillomavirus type 16 (HPV-16) sequence variation in tumor samples that were collected and analyzed in an international study of invasive cervical cancer may prove important for the determination of the risk of cervical neoplasia and for the design of HPV-16 vaccine strategies.
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