Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Book ChapterDOI
Human Papillomavirus Research in Latin America
TL;DR: The HPV vaccine was introduced in the national immunization programs of several LA countries, and multiple screening experiences using HPV testing were introduced inThe region.
Book ChapterDOI
Biological Pathways of HPV-Induced Carcinogenesis
TL;DR: The complex and intimately linked series of events of mucosal HPV-induced tumorigenesis, which is mostly clarified for HPV-associated cervical cancer, is still largely unknown for other HPV-driven cancers.
Dissertation
HPV strain prevalence and HPV-related biomarker expression in vulvar carcinoma at Tygerberg academic hospital.
TL;DR: HPV subtypes in vulvar intraepithelial neoplasia and iVSCC FFPE tissue are identified using quantitative real-time polymerase chain reaction (qPCR) and to correlate HPV strain prevalence results with HIV status, clinicopathological features and biomarker expression.
Dissertation
HPV 16 European variant and HPV 58 linage A2 associated with cancer in Ecuadorian women
Mejía Castañeda,María Lorena +1 more
TL;DR: This study characterized the HPV types responsible for malignancies associated with the genital tract in Ecuadorian women attending a major hospital in Quito to inform about the potential lower impact on reducing cervical cancer of the bivalent and tetravalent HPV vaccines currently in use in Ecuador.
Journal ArticleDOI
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Paramita Mandal,Bornali Bhattacharjee,Shrinka Sen,Amrapali Bhattacharya,Sweta Sharma Saha,Rahul Roy Chowdhury,Nidhu Ranjan Mondal,Biman Chakrabarty,Tanmay Chatterjee,Sudipta Roy,Sharmila Sengupta +10 more
TL;DR: In this article, the authors delineate the distinctive features of lineages among cervical squamous cell carcinoma (SCC) in the eastern region of India and highlight the distinctive modalities of oncogenicity among different HPV16 lineages.
References
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Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
Journal ArticleDOI
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
Journal ArticleDOI
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
Journal ArticleDOI
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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