Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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High-risk human papilloma virus genotypes in cervical carcinoma of Serbian women: Distribution and association with pathohistological findings.
Miodrag Stamenković,Aleksandra Knežević,Ivana Knežević,Igor Kuzmanović,Danijela Karalic,Sanja Milenkovic,Tanja Jovanovic +6 more
TL;DR: The high frequency of HPV 16 was observed in both types of carcinoma while the prevalence of HPV18 was low, which may contribute to the implementation of cervical carcinoma prevention program in Serbia, including the selection of the most appropriate vaccine and immunization program.
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HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization.
Roger Meisal,Trine B. Rounge,Irene Kraus Christiansen,Alexander Kirkeby Eieland,Merete Molton Worren,Tor Molden,Øyvind Kommedal,Eivind Hovig,Truls Michael Leegaard,Truls Michael Leegaard,Ole Herman Ambur,Ole Herman Ambur +11 more
TL;DR: Next Generation Sequencing was found to be the most specific method and expanded the detection repertoire beyond the 37 types of the DNA hybridization assay and provided an increased resolution by identifying genetic variants of individual HPV types.
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Utility of high-throughput DNA sequencing in the study of the human papillomaviruses
Noé Escobar-Escamilla,José Ernesto Ramírez-González,Graciela Castro-Escarpulli,José Alberto Díaz-Quiñonez +3 more
TL;DR: This review summarizes the main approaches and their perspectives where the use of massively parallel sequencing has been proved as a useful tool in the research of the HPV infection.
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HPV-18 E6 Oncoprotein and Its Spliced Isoform E6*I Regulate the Wnt/β-Catenin Cell Signaling Pathway through the TCF-4 Transcriptional Factor.
J. Omar Muñoz-Bello,Leslie Olmedo-Nieva,Leonardo Josué Castro-Muñoz,Joaquín Manzo-Merino,Adriana Contreras-Paredes,Claudia González-Espinosa,Alejandro López-Saavedra,Marcela Lizano +7 more
TL;DR: Investigation of the participation of HPV-18 E6 and E6*I, in the regulation of the Wnt/β-catenin signaling pathway shows that E6 proteins up-regulate TCF-4 transcriptional activity and promote overexpression of Wnt target genes, and data support that E 6 proteins cooperate with β- catenin to promote cell proliferation.
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Impact of naturally occurring variation in the human papillomavirus 52 capsid proteins on recognition by type-specific neutralising antibodies.
Anna Godi,Sara L. Bissett,Sara L. Bissett,Solène Masloh,Solène Masloh,Maxime Fleury,Shaowei Li,Qinjian Zhao,Ningshao Xia,Clementina Cocuzza,Simon Beddows +10 more
TL;DR: Analysis of naturally occurring variation within the major (L1) and minor (L2) capsid proteins on the antigenicity of human papillomavirus (HPV) type 52 contributes to the understanding of HPV L1 variant antigenicity.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
Journal ArticleDOI
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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