Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Journal ArticleDOI
Human Papillomavirus Genotypes and HPV16 E6/E7 Variants among Patients with Genital Cancers in Vietnam.
Trang Thi Thu Pham,Xiuqiong Bi,Huyen Thi Thanh Hoang,Azumi Ishizaki,Mai Thi Phuong Nguyen,Cuong Hung Nguyen,Hung Phi Nguyen,Thuc Van Pham,Hiroshi Ichimura +8 more
TL;DR: It is indicated that HPV16/18 accounts for more than 85% of genital cancers in Vietnam, and the HPV16 sublineage A4 containing E7 29S may be less oncogenic.
Journal ArticleDOI
HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures
Daniel L. Faden,Adam Langenbucher,Krystle A. Lang Kuhs,James S. Lewis,Lisa Mirabello,Meredith Yeager,Meredith Yeager,Joseph Boland,Joseph Boland,Sara Bass,Sara Bass,Mia Steinberg,Mia Steinberg,Michael Cullen,Michael Cullen,Michael S. Lawrence,Michael S. Lawrence,Robert L. Ferris +17 more
TL;DR: It is demonstrated that despite infection by the same viral isolate, paired mHPV+OPSCCs develop drastically different somatic alterations and even more strikingly, appear to be driven by disparate underlying mutational processes.
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Impact of Naturally Occurring Variation in the Human Papillomavirus 58 Capsid Proteins on Recognition by Type-Specific Neutralizing Antibodies.
Anna Godi,Marianna Martinelli,Marianna Martinelli,Mahmoud Haque,Shaowei Li,Qinjian Zhao,Ningshao Xia,Clementina Cocuzza,Simon Beddows +8 more
TL;DR: Comparing the HPV58 A1 L1 pentamer crystal structure and an HPV58 C homology model indicated that differences in neutralization sensitivity were likely due to subtle epitope sequence changes rather that major structural alterations.
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Methylation at 3'LCR of HPV16 can be affected by patient age and disruption of E1 or E2 genes.
Sérgio Menezes Amaro Filho,Neilane Bertoni,Ayslan Castro Brant,João Paulo C. B. Vidal,Shayany Pinto Felix,Silvia Maria Baeta Cavalcanti,Fernanda Nahoum Carestiato,Luís Felipe Leite Martins,Liz Maria de Almeida,Miguel A. M. Moreira +9 more
TL;DR: Findings showed that presence of intact E1/E2 open reading frames was associated with high levels of DNA methylation, and older patients showed higher levels of methylation than younger ones independently of viral genome disruption.
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Delineation of the HPV11E6 and HPV18E6 Pathways in Initiating Cellular Transformation.
TL;DR: It is suggested that HPV11E6 and HPV18E6 are important in initiating cellular transformation via deregulation of signaling pathways such as PI3K/AKT and pathways that are directly involved in DNA damage repair, cell survival, and cell proliferation.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
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Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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