Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Identification of novel human papillomavirus lineages and sublineages in HIV/HPV-coinfected pregnant women by next-generation sequencing.
Juliana D. Siqueira,Brunna M. Alves,Isabel M. Prellwitz,Carolina Furtado,Ângela R. Meyrelles,Elizabeth S. Machado,Héctor N. Seuánez,Marcelo A. Soares,Esmeralda A. Soares +8 more
TL;DR: Assessment of HPV multiple infection and variation from a cohort of highly susceptible, HIV(+) pregnant women using next-generation sequencing and an in-house pipeline for HPV full-length genome assembly proposes the classification of novel HPV lineages and sublineages across nine HPV types, including two high-risk types.
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Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates
Luc Magloire Anicet Boumba,Samira Zoa Assoumou,Lahoucine Hilali,Jean Victor Mambou,Donatien Moukassa,Mustapha Moulay Ennaji +5 more
TL;DR: The distribution of HPV-16 E6 and E7 genetic variants in infected women from southwest Congo is reported for the first time and the findings confirmed almost ascendancy of the African lineage in the study population.
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Prevalence of human papillomavirus types in cervical cancerous and precancerous lesions of Ecuadorian women
TL;DR: It is suggested that the currently used HPV vaccines (bivalent and tetravalent) may have lower effectiveness in Ecuador than in other geographic locations where HPV18 is more prevalent.
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The contribution of Latin American research to HPV epidemiology and natural history knowledge.
TL;DR: Data from large cohort studies conducted in LA countries provided seminal data to propose primary and secondary prevention modalities: the HPV vaccine has been introduced in the national immunization programs of several LA countries and multiple screening experiences using HPV testing are under evaluation in the region.
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Cancer stages and demographical study of HPV16 in gene L2 isolated from cervical cancer in Dhi-Qar province, Iraq
Abduladheem Turki Jalil,Wesam R. Kadhum,Muhammad Usman Faryad Khan,Aleksandr Karevskiy,Zaman K. Hanan,Wanich Suksatan,Azal Shakir Waheeb,Masar Ali Awad,Mays Mohammed Abdullah +8 more
TL;DR: The most carcinogenic form of the HPV is the high-risk human papillomavirus 16 (hrHPV16) as mentioned in this paper, however, only a few hrHPV 16 infections develop into cancer.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
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Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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