Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Journal ArticleDOI
Detection of HPV16 African variants and quantitative analysis of viral DNA methylation in oropharyngeal squamous cell carcinomas
Daniela Barbieri,Aurel Nebiaj,Rosaria Strammiello,Roberto Agosti,Silvia Sciascia,Giorgio Gallinella,Maria Paola Landini,U. Caliceti,Simona Venturoli +8 more
TL;DR: The results highlight both the involvement of HPV16 African variants in OPSCCs development and the necessity of further studies to deepen the role of viral methylation in these tumors, in order to better define similarities/differences compared to cervical cancer.
Journal ArticleDOI
Functional evaluation of human papillomavirus type 31 long control region variants.
R. C. O. Silva,Rita de Cássia Pereira de Lima,M. N. Cordeiro,D. L. Santos,Lindomar Pena,Ana Pavla Almeida Diniz Gurgel,Marcus Vinicius de Aragão Batista,Bárbara Simas Chagas,Antonio Carlos de Freitas +8 more
TL;DR: A more refined profile of variants of HPV-31 and its importance for the prognosis of cervical lesions begins to be drawn.
Journal ArticleDOI
Association of HLA-A, -B, DRB, and DQB Alleles with Persistent HPV-16 Infection in Women from Tamil Nadu, India.
Muthumeenakshi Bhaskaran,Sree Varshini Murali,Barathi Rajaram,Sundar Krishnasamy,C. S. Devasena,Atima Pathak,Vidhya Ravi,Krishnan Swaminathan,Ashok Ayyappa,Srinivasan Vedhantham,Arun Seshachalam,GaneshPrasad ArunKumar +11 more
TL;DR: Larger studies on high-resolution HLA typing coupled with HPV-16 genome diversity will offer further insights into host/pathogen genome coevolution.
Posted ContentDOI
Virus-host protein-protein interactions between human papillomavirus 16 E6 A1 and D2/D3 sub-lineages: variances and similarities
TL;DR: The current data underline the lab’s driving hypothesis that E6, being a “master regulator” in HPV-positive cancers, is an excellent candidate for anti-cancer treatment strategies and confirm the candidacy of the E6 protein as a viable target for HPV therapies.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
TL;DR: UNLABELLED RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML) that has been used to compute ML trees on two of the largest alignments to date.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
TL;DR: MUSCLE offers a range of options that provide improved speed and / or alignment accuracy compared with currently available programs, and a new option, MUSCLE-fast, designed for high-throughput applications.
Journal ArticleDOI
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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