Human papillomavirus genome variants.
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TLDR
These studies provide the basis to define the genetics of HPV pathogenesis and the use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 346 citations till now. The article focuses on the topics: Genome & Population.read more
Citations
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Journal ArticleDOI
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
Zheng Hu,Da Zhu,Wei Wang,Weiyang Li,Wenlong Jia,Xi Zeng,Wencheng Ding,Lan Yu,Xiaoli Wang,Liming Wang,Hui Shen,Changlin Zhang,Hongjie Liu,Xiao Liu,Yi Zhao,Xiaodong Fang,Shuai Cheng Li,Wei Chen,Tang Tang,Aisi Fu,Zou Wang,Gang Chen,Qinglei Gao,Shuang Li,Ling Xi,Changyu Wang,Shujie Liao,Xiangyi Ma,Peng Wu,Kezhen Li,Shixuan Wang,Jianfeng Zhou,Wang Jun,Xun Xu,Hui Wang,Ding Ma +35 more
TL;DR: Microhomologous sequence between the human and HPV genomes was significantly enriched near integration breakpoints, indicating that fusion between viral and human DNA may have occurred by microhomology-mediated DNA repair pathways.
Journal ArticleDOI
The natural history of human papillomavirus infection.
TL;DR: Viral load and viral type are the main cofactors for progression from infection to cervical intraepithelial lesions and cancer and the adverse health effects of HPV infections can be largely controlled through vaccination and screening.
Journal ArticleDOI
HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis
Lisa Mirabello,Meredith Yeager,Kai Yu,Gary M. Clifford,Yanzi Xiao,Bin Zhu,Michael Cullen,Michael Cullen,Joseph Boland,Joseph Boland,Nicolas Wentzensen,Chase W. Nelson,Tina Raine-Bennett,Zigui Chen,Sara Bass,Sara Bass,Lei Song,Lei Song,Qi Yang,Qi Yang,Mia Steinberg,Mia Steinberg,Laurie Burdett,Laurie Burdett,Michael Dean,David Roberson,David Roberson,Jason Mitchell,Jason Mitchell,Thomas Lorey,Silvia Franceschi,Philip E. Castle,Joan L. Walker,Rosemary E. Zuna,Aimée R. Kreimer,Daniel C. Beachler,Allan Hildesheim,Paula Gonzalez,Carolina Porras,Robert D. Burk,Mark Schiffman +40 more
TL;DR: Strict conservation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic research.
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Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives
TL;DR: In spite of the successful implementation of the HPV vaccination program in many countries all over the world, problems related to HPV prevention and treatment of the related diseases will continue to persist in developing and underdeveloped countries.
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The precision prevention and therapy of HPV-related cervical cancer: new concepts and clinical implications.
TL;DR: The fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients.
References
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Journal ArticleDOI
Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52, and 58, four close relatives of human papillomavirus type 16
Itzel E. Calleja-Macias,Luisa L. Villa,Jose C. Prado,Mina Kalantari,Bruce Allan,Anna-Lise Williamson,Lap Ping Chung,R. J. Collins,Rosemary E. Zuna,S. Terence Dunn,Tang Yuan Chu,Heather A. Cubie,Kate Cuschieri,Magnus von Knebel-Doeberitz,Cláudia R. F. Martins,Gloria I. Sanchez,F. Xavier Bosch,Nubia Muñoz,Hans-Ulrich Bernard,Hans-Ulrich Bernard +19 more
TL;DR: This study addresses the question of whether geography and ethnicity also correlate with sequence variations found for HPV-31, -35, -52, and -58 by sequencing the long control region in samples derived from Europe, Asia, and Africa, and from immigrant populations in North and South America.
Journal ArticleDOI
Variation of human papillomavirus type 6 (HPV-6) and HPV-11 genomes sampled throughout the world.
P A Heinzel,Shih-Yen Chan,L. C. Ho,M O'Connor,P Balaram,M S Campo,Kei Fujinaga,N Kiviat,J Kuypers,H Pfister +9 more
TL;DR: Functional analysis of diverse enhancer variants showed activities that differed two-to threefold, and it must be considered that transcriptional differences may alter the biology or pathology of these viruses.
Journal ArticleDOI
Coevolution of papiliomaviruses with human populations
TL;DR: The human papillomavirus types that are causally linked to genital cancer originated in ancient times in prehuman primates and the molecular diversity of viral isolates reflects the African origins and the subsequent worldwide spread of human races.
Journal ArticleDOI
Genomic diversity of human papillomavirus-16, 18, 31, and 35 isolates in a Mexican population and relationship to European, African, and Native American variants.
Itzel E. Calleja-Macias,Mina Kalantari,John Huh,Rocio Ortiz-Lopez,Augusto Rojas-Martinez,Juan Francisco González-Guerrero,Anna-Lise Williamson,Björn Hagmar,Dorothy J. Wiley,Luis P. Villarreal,Hans-Ulrich Bernard,Hugo A. Barrera-Saldaña +11 more
TL;DR: The research suggests type specific patterns of evolution and spread of HPV-16, 18, 31, and 35 both before and after the worldwide migrations of the last four centuries.
Journal ArticleDOI
High throughput sequencing reveals diversity of Human Papillomaviruses in cutaneous lesions
Johanna Ekström,Davit Bzhalava,Davit Bzhalava,Daniel Svenback,Ola Forslund,Joakim Dillner,Joakim Dillner,Joakim Dillner +7 more
TL;DR: High throughput sequencing was an effective means to identify both known and previously unknown HPV types in putatively HPV‐associated lesions and has revealed an extended diversity of HPV types.
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