Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
Citations
More filters
Proceedings ArticleDOI
Regional lung ventilation estimation based on supervoxel tracking.
Adam Szmul,Bartlomiej W. Papiez,Tahreema N. Matin,Fergus V. Gleeson,Julia A. Schnabel,Julia A. Schnabel,Vicente Grau +6 more
TL;DR: A novel approach for regional lung ventilation estimation from dynamic lung CT imaging, which might be used during radiotherapy planning, that combines a supervoxel-based image representation with deformable image registration, performed between peak breathing phases, for which it has the potential to mimic the lung anatomy.
Journal ArticleDOI
Automated Low-Cost In Situ IR and NMR Spectroscopy Characterization of Clinical-Scale 129Xe Spin-Exchange Optical Pumping.
Jonathan R Birchall,Robert K. Irwin,Raduanul H. Chowdhury,Panayiotis Nikolaou,Boyd M. Goodson,Michael J. Barlow,Anton Shcherbakov,Eduard Y. Chekmenev,Eduard Y. Chekmenev +8 more
Abstract: We present on the utility of in situ nuclear magnetic resonance (NMR) and near-infrared (NIR) spectroscopic techniques for automated advanced analysis of the 129Xe hyperpolarization process during spin-exchange optical pumping (SEOP). The developed software protocol, written in the MATLAB programming language, facilitates detailed characterization of hyperpolarized contrast agent production efficiency based on determination of key performance indicators, including the maximum achievable 129Xe polarization, steady-state Rb-129Xe spin-exchange and 129Xe polarization build-up rates, 129Xe spin-relaxation rates, and estimates of steady-state Rb electron polarization. Mapping the dynamics of 129Xe polarization and relaxation as a function of SEOP temperature enables systematic optimization of the batch-mode SEOP process. The automated analysis of a typical experimental data set, encompassing ∼300 raw NMR and NIR spectra combined across six different SEOP temperatures, can be performed in under 5 min on a laptop computer. The protocol is designed to be robust in operation on any batch-mode SEOP hyperpolarizer device. In particular, we demonstrate the implementation of a combination of low-cost NIR and low-frequency NMR spectrometers (∼$1,100 and ∼$300 respectively, ca. 2020) for use in the described protocols. The demonstrated methodology will aid in the characterization of NMR hyperpolarization hardware in the context of SEOP and other hyperpolarization techniques for more robust and less expensive clinical production of HP 129Xe and other contrast agents.
A Heterogeneous Patient-Specific Biomechanical Model of the Lung for Tumor Motion Compensation and Effective Lung Radiation Therapy Planning
TL;DR: This book aims to provide a forum for discussion and discussion of the role of emotion and self-consistency in decision-making in the rapidly changing environment.
Journal ArticleDOI
Longitudinal nuclear spin relaxation of 129Xe in solution and in hollow fiber membranes at low and high magnetic field strengths
TL;DR: In this article , hollow fiber membranes were used to infuse hyperpolarized xenon in solution to measure dissolved phase T1 values at high and low magnetic fields and the field dependence of 129Xe depolarization.
Journal ArticleDOI
Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate
Isaiah Adelabu,Raduanul H. Chowdhury,Shiraz Nantogma,Clementinah Oladun,Firoz Ahmed,Lukas Stilgenbauer,Marianna Sadagurski,Thomas Theis,Boyd M. Goodson,Eduard Y. Chekmenev +9 more
TL;DR: Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) as mentioned in this paper enables spontaneous polarization transfer from parahydrogen-derived hydrides to the 13C nucleus of transiently bound ketoisocaproate.
References
More filters
Journal ArticleDOI
Biological magnetic resonance imaging using laser-polarized 129Xe
Mitchell S. Albert,Gordon D. Cates,Bastiaan Driehuys,William Happer,Brian Saam,Charles Jr Springer,Arnold Wishnia +6 more
TL;DR: It is shown that 129Xe gas can be used for high-resolution MRI when the nuclear-spin polarization of the atoms is increased by laser optical pumping and spin exchange, which produces hyperpolarized 129xe, in which the magnetization is enhanced by a factor of about 105.
Journal ArticleDOI
The intrinsic signal-to-noise ratio in NMR imaging.
TL;DR: The intrinsic and system SNR is applied to predict image SNR and has found satisfactory agreement with measurements on images, which indicates that the initial choice of pixel size is crucial in NMR.
Journal ArticleDOI
Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms
TL;DR: The theory of spin exchange between optically pumped alkali-inetal atoms and noble-gas nuclei is presented in this article, where the main spin interactions are assumed to be the spin-rotation interactions yN S between the rotational angular momentum N of the alkali ion and the electron spin S of the noble ion.
Journal ArticleDOI
MRI of the lungs using hyperpolarized noble gases.
Harald E. Möller,X. Josette Chen,Brian Saam,Klaus D. Hagspiel,G. Allan Johnson,Talissa A. Altes,Eduard E. de Lange,Hans-Ulrich Kauczor +7 more
TL;DR: The physics underlying the optical pumping process, imaging strategies coping with the nonequilibrium polarization, and effects of the alveolar microstructure on relaxation and diffusion of the noble gases are outlined.
Journal ArticleDOI
MR imaging with hyperpolarized 3He gas.
H. Middleton,H. Middleton,Robert D. Black,Brian Saam,Gordon D. Cates,Gary P. Cofer,Robert D. Guenther,William Happer,L.W. Hedlund,G. Alan Johnson,Kim Juvan,J. C. Swartz +11 more
TL;DR: Various unique features associated with performing MRI with hyperpolarized gases, such as the selection of the noble gas species, polarization technique, and constraints on the MR pulse sequence are discussed.