Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
Citations
More filters
Journal ArticleDOI
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
TL;DR: This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety and efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives.
Journal ArticleDOI
CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society.
David A. Lynch,John H. M. Austin,John H. M. Austin,James C. Hogg,Philippe Grenier,Hans-Ulrich Kauczor,Alexander A. Bankier,R. Graham Barr,Thomas V. Colby,Jeffrey R. Galvin,Pierre-Alain Gevenois,Harvey O. Coxson,Eric A. Hoffman,John D. Newell,Massimo Pistolesi,Edwin K. Silverman,James D. Crapo +16 more
TL;DR: The classification system proposed and illustrated in this article provides a structured approach to visual and quantitative assessment of COPD and helps to contribute to a personalized approach to the treatment of patients with COPD.
Journal ArticleDOI
NMR Hyperpolarization Techniques for Biomedicine
TL;DR: This article explores selected advances in methods for the preparation and use of hyperpolarized contrast agents, many of which are already at or near the phase of their clinical validation in patients.
Journal ArticleDOI
15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH
Milton L. Truong,Thomas Theis,Aaron M. Coffey,Roman V. Shchepin,Kevin W. Waddell,Fan Shi,Boyd M. Goodson,Warren S. Warren,Eduard Y. Chekmenev +8 more
TL;DR: This method enables hyperpolarization of molecular sites with NMR T1 relaxation times suitable for biomedical imaging and spectroscopy and provides large enough signal gains to enable one of the first 15N images (2 × 2 mm2 resolution).
Journal ArticleDOI
NMR Hyperpolarization Techniques of Gases.
Danila A. Barskiy,Aaron M. Coffey,Panayiotis Nikolaou,Dmitry M. Mikhaylov,Boyd M. Goodson,Rosa T. Branca,George J. Lu,Mikhail G. Shapiro,Ville-Veikko Telkki,Vladimir V. Zhivonitko,Igor V. Koptyug,Oleg G. Salnikov,Kirill V. Kovtunov,Valerii I. Bukhtiyarov,Matthew S. Rosen,Michael J. Barlow,Shahideh Safavi,Ian P. Hall,Leif Schröder,Eduard Y. Chekmenev,Eduard Y. Chekmenev +20 more
TL;DR: This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.
References
More filters
Journal ArticleDOI
MRI of helium-3 gas in healthy lungs: posture related variations of alveolar size.
Stanislao Fichele,Neil Woodhouse,Andrew J. Swift,Zead Said,Martyn N.J. Paley,Larry Kasuboski,Gary H. Mills,Edwin J. R. van Beek,Jim M. Wild,Jim M. Wild +9 more
TL;DR: To probe the variation of alveolar size in healthy lung tissue as a function of posture using diffusion‐weighted helium‐3 hyperpolarized gas imaging.
Journal ArticleDOI
Hyperpolarized Xenon-129 gas-exchange imaging of lung microstructure: first case studies in subjects with obstructive lung disease.
Isabel Dregely,John P. Mugler,Iulian C. Ruset,Talissa A. Altes,Jaime F. Mata,G. Wilson Miller,Jeffrey Ketel,Steve Ketel,Jan Distelbrink,F. W. Hersman,F. W. Hersman,Kai Ruppert +11 more
TL;DR: To develop and test a method to noninvasively assess the functional lung microstructure and to test the method's applicability to clinical practice.
Journal ArticleDOI
CPMG measurements and ultrafast imaging in human lungs with hyperpolarized helium-3 at low field (0.1 T).
Emmanuel Durand,Geneviève Guillot,Luc Darrasse,Geneviève Tastevin,Pierre-Jean Nacher,Alexandre Vignaud,D. Vattolo,Jacques Bittoun +7 more
TL;DR: The use of single‐shot spin echo sequences to achieve in vivo diffusion gas measurements and ultrafast imaging of human lungs, in vivo, with hyperpolarized 3He at 0.1 T supports the idea that low‐field imagers can be used for hyperpolarsized noble gas MRI of lungs and may be preferred for ADC measurements.
Journal ArticleDOI
Diffusion of hyperpolarized 129 Xe in the lung: a simplified model of 129 Xe septal uptake and experimental results
Samuel Patz,Iga Muradyan,Mirko I. Hrovat,Mikayel Dabaghyan,George R. Washko,Hiroto Hatabu,James P. Butler,James P. Butler +7 more
TL;DR: These are the first noninvasive, non-radiation-based, quantitative measurements of h and ?
Journal ArticleDOI
Determination of regional VA/Q by hyperpolarized 3He MRI.
Rahim R. Rizi,James E. Baumgardner,Masaru Ishii,Zebulon Z. Spector,Johan M. Edvinsson,Aman Jalali,Jiangsheng Yu,Maxim Itkin,David A. Lipson,Warren B. Gefter +9 more
TL;DR: Regional VA/Q was calculated from regional values of alveolar partial pressure of oxygen measured by hyperpolarized 3He gas MRI, indicating that HP 3He MRI may be an accurate, quantitative, noninvasive, and nonradioactive method for acquiringVA/Q for small regions of the lung.