Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
Citations
More filters
Journal ArticleDOI
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
TL;DR: This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety and efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives.
Journal ArticleDOI
CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society.
David A. Lynch,John H. M. Austin,John H. M. Austin,James C. Hogg,Philippe Grenier,Hans-Ulrich Kauczor,Alexander A. Bankier,R. Graham Barr,Thomas V. Colby,Jeffrey R. Galvin,Pierre-Alain Gevenois,Harvey O. Coxson,Eric A. Hoffman,John D. Newell,Massimo Pistolesi,Edwin K. Silverman,James D. Crapo +16 more
TL;DR: The classification system proposed and illustrated in this article provides a structured approach to visual and quantitative assessment of COPD and helps to contribute to a personalized approach to the treatment of patients with COPD.
Journal ArticleDOI
NMR Hyperpolarization Techniques for Biomedicine
TL;DR: This article explores selected advances in methods for the preparation and use of hyperpolarized contrast agents, many of which are already at or near the phase of their clinical validation in patients.
Journal ArticleDOI
15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH
Milton L. Truong,Thomas Theis,Aaron M. Coffey,Roman V. Shchepin,Kevin W. Waddell,Fan Shi,Boyd M. Goodson,Warren S. Warren,Eduard Y. Chekmenev +8 more
TL;DR: This method enables hyperpolarization of molecular sites with NMR T1 relaxation times suitable for biomedical imaging and spectroscopy and provides large enough signal gains to enable one of the first 15N images (2 × 2 mm2 resolution).
Journal ArticleDOI
NMR Hyperpolarization Techniques of Gases.
Danila A. Barskiy,Aaron M. Coffey,Panayiotis Nikolaou,Dmitry M. Mikhaylov,Boyd M. Goodson,Rosa T. Branca,George J. Lu,Mikhail G. Shapiro,Ville-Veikko Telkki,Vladimir V. Zhivonitko,Igor V. Koptyug,Oleg G. Salnikov,Kirill V. Kovtunov,Valerii I. Bukhtiyarov,Matthew S. Rosen,Michael J. Barlow,Shahideh Safavi,Ian P. Hall,Leif Schröder,Eduard Y. Chekmenev,Eduard Y. Chekmenev +20 more
TL;DR: This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.
References
More filters
Journal ArticleDOI
Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe
TL;DR: The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized 129Xe NMR spectroscopy is demonstrated and the method is demonstrated to distinguish two main aspects of lung function, namely, diffuding capacity and pulmonary perfusion.
Journal ArticleDOI
Assessment of a single‐acquisition imaging sequence for oxygen‐sensitive 3He‐MRI
Anselm Deninger,Balthasar Eberle,J. Bermuth,B. Escat,Klaus Markstaller,Jörg Schmiedeskamp,Wolfgang Schreiber,Reinhard Surkau,Ernst-Wilhelm Otten,Hans-Ulrich Kauczor +9 more
TL;DR: A new imaging strategy to measure pO2 by a single series of consecutive scans is presented, and the feasibility of the method is demonstrated in three healthy human volunteers.
Journal ArticleDOI
NMR of hyperpolarized 129Xe in the canine chest: spectral dynamics during a breath‐hold
TL;DR: Spectroscopy experiments performed in the canine chest to elucidate the behavior of xenon exchange in the lung found that the integrals of the dissolved‐phase resonances approached plateau values within approximately 200 ms, and then increased again after approximately 1 s, which suggests an early saturation of the parenchyma before xenon reaches downstream compartments.
Journal ArticleDOI
Assessment of lung development using hyperpolarized helium-3 diffusion MR imaging.
TL;DR: To determine whether hyperpolarized helium‐3 (HHe) diffusion MR can detect the expected enlargement of alveoli that occurs with lung growth during childhood, a diffusion MR study of HHe‐3 diffusion during childhood is conducted.
Journal ArticleDOI
Longitudinal relaxation and diffusion measurements using magnetic resonance signals from laser-hyperpolarized 129Xe nuclei.
Baldev R. Patyal,Jia-Hong Gao,Robert F. Williams,John W Roby,Brian Saam,Benjamin A. Rockwell,Robert J. Thomas,David J. Stolarski,Peter T. Fox +8 more
TL;DR: The methods were applied to 129Xe in the gas phase, in vitro; however, they are, in principle, applicable for in vivo or ex vivo studies, and the potential role of these methods in the development of newly emerging hyper-polarized 129xe MRI applications is discussed.