Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
Citations
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Simultaneous Determination of the Spin Polarizations of Noble-Gas and Alkali-Metal Atoms Based on the Dynamics of the Spin Ensembles
TL;DR: In this article, a method for simultaneously measuring the spin polarizations of noble-gas and alkali-metal atoms was presented. But the method was performed on a comagnetometer with various operation temperatures and pump-light intensities and the measured polarizations were consistent with the theoretical model and were also verified by the traditional polarization-measurement method.
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Parahydrogen‐induced Hyperpolarization of Gases
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Physiological gas exchange mapping of hyperpolarized 129Xe using spiral-IDEAL and MOXE in a model of regional radiation-induced lung injury
TL;DR: This work demonstrates the feasibility of mapping gas exchange using dissolved hyperpolarized HP 129 Xe in an animal model of RILI 4 weeks postirradiation and holds promise for assessing regional lung function in RILi and other pulmonary diseases.
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References
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Journal ArticleDOI
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Journal ArticleDOI
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