Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
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References
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Journal ArticleDOI
Human Pulmonary Imaging and Spectroscopy with Hyperpolarized 129Xe at 0.2T
Samuel Patz,Iga Muradian,Mirko I. Hrovat,Iulian C. Ruset,Iulian C. Ruset,George P. Topulos,Silviu Covrig,Eric Frederick,Hiroto Hatabu,F. W. Hersman,F. W. Hersman,James P. Butler +11 more
TL;DR: Hyperpolarized (129)Xe human imaging and spectroscopy are very promising methods to provide functional information about the lung in a manner very similar to that observed from histology measurements.
Journal ArticleDOI
Distribution and dynamics of laser-polarized 129Xe magnetization in vivo
TL;DR: These observations demonstrate the utility of laser‐polarized 129Xe to detect exchange across the gas‐blood barrier in the lungs and perfusion into myocardial tissue and applications to measurement of lung function, kidney perfusion, myocardia perfusions, and regional cerebral blood flow are discussed.
Journal ArticleDOI
Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI.
Sean B. Fain,Talissa A. Altes,Talissa A. Altes,Shilpa R. Panth,Michael D. Evans,Barnaby Waters,John P. Mugler,Frank R. Korosec,Thomas M. Grist,Michael Silverman,Michael Salerno,John Owers-Bradley +11 more
TL;DR: Results suggest the observed age dependence of the ADC may be caused by changes in lung microstructure that increase alveolar volume during the aging process.
Journal ArticleDOI
Exploring lung function with hyperpolarized 129Xe nuclear magnetic resonance
TL;DR: By exploiting the gas‐exchange process in the lung to encode physiologic parameters, these methods may be extended to noninvasive regional assessments of lung‐tissue density and the alveolar surface‐to‐volume ratio, and allow lung pathology to be detected at an earlier stage than is currently possible.
Journal ArticleDOI
In vivo He-3 MR images of guinea pig lungs.
Robert D. Black,H. Middleton,Gordon D. Cates,Gary P. Cofer,Bastiaan Driehuys,William Happer,Laurence W. Hedlund,G. A. Johnson,Mark D. Shattuck,J. C. Swartz +9 more
TL;DR: The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.