Hyperpolarized 129Xe MRI of the human lung
John P. Mugler,Talissa A. Altes +1 more
TLDR
Preliminary results from methods for imaging 129Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden the understanding of lung disease.Abstract:
By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging (MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary structure and function. Although the vast majority of research in humans has been performed using hyperpolarized (3)He, recent contraction in the supply of (3)He and consequent increases in price have turned attention to the alternative agent, hyperpolarized (129) Xe. Compared to (3)He, (129)Xe yields reduced signal due to its smaller magnetic moment. Nonetheless, taking advantage of advances in gas-polarization technology, recent studies in humans using techniques for measuring ventilation, diffusion, and partial pressure of oxygen have demonstrated results for hyperpolarized (129)Xe comparable to those previously demonstrated using hyperpolarized (3)He. In addition, xenon has the advantage of readily dissolving in lung tissue and blood following inhalation, which makes hyperpolarized (129)Xe particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake, which cannot be accessed using (3)He. Preliminary results from methods for imaging (129) Xe dissolved in the human lung suggest that these approaches will provide new opportunities for quantifying relationships among gas delivery, exchange, and transport, and thus show substantial potential to broaden our understanding of lung disease. Finally, recent changes in the commercial landscape of the hyperpolarized-gas field now make it possible for this innovative technology to move beyond the research laboratory.read more
Citations
More filters
Journal ArticleDOI
Fast dynamic ventilation MRI of hyperpolarized 129 Xe using spiral imaging.
Ozkan Doganay,Tahreema N. Matin,Anthony McIntyre,Brian Burns,Rolf F. Schulte,Fergus V. Gleeson,Daniel P. Bulte +6 more
TL;DR: To develop and optimize a rapid dynamic hyperpolarized 129Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal‐time curves in human lungs.
Journal ArticleDOI
Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium.
Peter Niedbalski,Chase S. Hall,Mario Castro,Rachel L. Eddy,Jonathan H. Rayment,Sarah Svenningsen,Grace Parraga,Brandon Zanette,Giles E. Santyr,Robert P. Thomen,Neil J. Stewart,Guilhem Collier,Ho-Fung Chan,Jim M. Wild,Sean B. Fain,G. Wilson Miller,Jaime F. Mata,John P. Mugler,Bastiaan Driehuys,Matthew M. Willmering,Zackary I. Cleveland,Jason C. Woods +21 more
TL;DR: In this article, a position paper from the 129 Xe MRI Clinical Trials Consortium (https://cpir.cchmc.org/XeMRICTC) recommends standard protocols to harmonize methods for image acquisition in Hyperpolarized (HP) 129Xe MRI.
Journal Article
Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers
Panayiotis Nikolaou,Aaron M. Coffey,Kaili Ranta,Laura L. Walkup,Brogan M. Gust,Michael J. Barlow,Matthew S. Rosen,Boyd M. Goodson,Eduard Y. Chekmenev +8 more
TL;DR: In this paper, a systematic, multiparameter study of Rb/¹¹Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer is presented.
Journal ArticleDOI
Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.
Nicola J. Rogers,Fraser Hill-Casey,Karl F. Stupic,Joseph S. Six,Clémentine Lesbats,Sean P. Rigby,Jacques Fraissard,Galina E. Pavlovskaya,Thomas Meersmann +8 more
TL;DR: Highly spin-polarized 83Kr can now be purified for the first time, to the authors' knowledge, to provide high signal intensity for the advancement of in vivo hp 83kr MRI.
Journal ArticleDOI
Magnetic Resonance of Brown Adipose Tissue: A Review of Current Techniques.
TL;DR: This article reviews recent efforts in magnetic resonance imaging (MRI) and spectroscopy (MRS) of brown adipose tissues (BAT) and provides an outlook on research opportunities and future directions.
References
More filters
Journal ArticleDOI
Biological magnetic resonance imaging using laser-polarized 129Xe
Mitchell S. Albert,Gordon D. Cates,Bastiaan Driehuys,William Happer,Brian Saam,Charles Jr Springer,Arnold Wishnia +6 more
TL;DR: It is shown that 129Xe gas can be used for high-resolution MRI when the nuclear-spin polarization of the atoms is increased by laser optical pumping and spin exchange, which produces hyperpolarized 129xe, in which the magnetization is enhanced by a factor of about 105.
Journal ArticleDOI
The intrinsic signal-to-noise ratio in NMR imaging.
TL;DR: The intrinsic and system SNR is applied to predict image SNR and has found satisfactory agreement with measurements on images, which indicates that the initial choice of pixel size is crucial in NMR.
Journal ArticleDOI
Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms
TL;DR: The theory of spin exchange between optically pumped alkali-inetal atoms and noble-gas nuclei is presented in this article, where the main spin interactions are assumed to be the spin-rotation interactions yN S between the rotational angular momentum N of the alkali ion and the electron spin S of the noble ion.
Journal ArticleDOI
MRI of the lungs using hyperpolarized noble gases.
Harald E. Möller,X. Josette Chen,Brian Saam,Klaus D. Hagspiel,G. Allan Johnson,Talissa A. Altes,Eduard E. de Lange,Hans-Ulrich Kauczor +7 more
TL;DR: The physics underlying the optical pumping process, imaging strategies coping with the nonequilibrium polarization, and effects of the alveolar microstructure on relaxation and diffusion of the noble gases are outlined.
Journal ArticleDOI
MR imaging with hyperpolarized 3He gas.
H. Middleton,H. Middleton,Robert D. Black,Brian Saam,Gordon D. Cates,Gary P. Cofer,Robert D. Guenther,William Happer,L.W. Hedlund,G. Alan Johnson,Kim Juvan,J. C. Swartz +11 more
TL;DR: Various unique features associated with performing MRI with hyperpolarized gases, such as the selection of the noble gas species, polarization technique, and constraints on the MR pulse sequence are discussed.