IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression
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TLDR
In this paper, the authors performed a comprehensive meta-analysis to establish association between induced cytokines and COVID-19 disease severity to help in prognosis and clinical care, using a logistic regression model with cytokines having significant SMD as covariates.About:
This article is published in Heliyon.The article was published on 2021-01-29 and is currently open access. It has received 98 citations till now. The article focuses on the topics: Meta-analysis.read more
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Journal ArticleDOI
Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning.
Bruce K. Patterson,Jose Guevara-Coto,Ram Yogendra,Edgar B. Francisco,Emily Long,Amruta Pise,Hallison Rodrigues,Purvi Parikh,Javier Mora,Rodrigo Mora-Rodriguez +9 more
TL;DR: In this paper, the role of CCR5 and its ligands across the immunologic spectrum of COVID-19 was explored using a bioinformatics approach to predict and model the immunological phases of the virus pathogenesis.
Journal ArticleDOI
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Jesus Silvas,Desarey Morales Vasquez,Jun-Gyu Park,Kevin Chiem,Anna Allué-Guardia,Andreu Garcia-Vilanova,Roy N. Platt,Lisa Miorin,Thomas Kehrer,Anastasija Cupic,Ana S. Gonzalez-Reiche,Harm van Bakel,Adolfo García-Sastre,Tim J. Anderson,Jordi B. Torrelles,Chengjin Ye,Luis Martinez-Sobrido +16 more
TL;DR: In this article, a reverse-genetics system was used to generate recombinant SARS-CoV-2 (rSARSCoV2) constructs, and the resulting recombinant viruses were characterized in vitro and in vivo.
Journal ArticleDOI
The acid sphingomyelinase/ceramide system in COVID-19.
TL;DR: In this article, the authors showed that SARS-CoV-2 uses these platforms for cell entry, and the addition of ceramide restored infection with SARS CoV2.
Journal ArticleDOI
Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?
TL;DR: In this article, the SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swab of COVID-19 patients.
Journal ArticleDOI
Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 Patients.
Shubham Shrivastava,Shweta Chelluboina,Prashant Jedge,Purwa Doke,Sonali Palkar,Akhilesh Chandra Mishra,Vidya A. Arankalle +6 more
TL;DR: In this article, the authors compared the levels of DEFA1, S100A8/A9 and MPO in COVID-19 patients with different clinical presentations and found that DEFA 1 levels were higher in severe than mild patients in first week of onset of disease (p=0.004).
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China.
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