Journal ArticleDOI
Impaired antioxidant status in diabetic rat liver : effect of vanadate
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TLDR
The results suggest that vanadate, an insulin-mimetic agent, effectively normalized hyperglycemia, but unlike insulin, could not completely restore the altered endogenous defence mechanisms in diabetic liver.About:
This article is published in Biochemical Pharmacology.The article was published on 1993-02-09. It has received 228 citations till now. The article focuses on the topics: Glutathione peroxidase & Glutathione reductase.read more
Citations
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Diabetes, oxidative stress, and antioxidants: a review
TL;DR: There is a need to continue to explore the relationship between free radicals, diabetes, and its complications, and to elucidate the mechanisms by which increased oxidative stress accelerates the development of diabetic complications, in an effort to expand treatment options.
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Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options.
TL;DR: Recognition of upstream and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal damage as well as free radical scavenging.
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The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds.
TL;DR: Aqueous V(III) Chemistry 877 6.2.1.
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Vanadium in cancer treatment.
TL;DR: Vanadium possesses low toxicity that, in combination with the synthesis of new, more potent and better tolerated complexes, may establish vanadium as an effective non-platinum, metal antitumor agent.
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Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin.
TL;DR: Garlic oil or melatonin may effectively normalize the impaired antioxidants status in streptozotocin induced-diabetes and may be useful in delaying the complicated effects of diabetes as retinopathy, nephropathy and neuropathy due to imbalance between free radicals and antioxidant systems.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
TL;DR: It is reported here that 2-vinylpyridine is a much better reagent for the derivitization of glutathione, and it is demonstrated that the total glutATHione concentration in mouse plasma is substantially higher than generally reported and that glutathion disulfide constitutes less than 30% of the totalglutathione present.
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Glutathione peroxidase activity in selenium-deficient rat liver☆
TL;DR: Two peaks of glutathione peroxidase activity were present in the Sephadex G-150 gel filtration chromatogram of rat liver supernatant when 1.5 mM cumene hydroperoxide was used as substrate, and the second peak represents a second glutathienase activity which catalyzes the destruction of organic hydroperoxides but has little activity toward H 2 O 2 and which persists in severe selenium deficiency.
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Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes.
Simon P. Wolff,Roger T. Dean +1 more
TL;DR: It is suggested that a component of protein glycosylation is dependent upon glucose autoxidation and subsequent covalent attachment of ketoaldehydes, and the chemical evidence for the currently accepted 'Amadori' product is consistent with the structure expected for the attachment of a glucose-derived ketoaldehyde to protein.