Journal ArticleDOI
In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells.
Jorge B. Aquino,Jens Hjerling-Leffler,Martin Koltzenburg,Thomas Edlund,Marcelo J. Villar,Patrik Ernfors +5 more
Reads0
Chats0
TLDR
Results show that, under appropriate conditions, bNCSCs can generate mature SCs that are functional and can myelinate axons in regenerating nerves.About:
This article is published in Experimental Neurology.The article was published on 2006-04-01. It has received 121 citations till now. The article focuses on the topics: Neurosphere & Adult stem cell.read more
Citations
More filters
Journal ArticleDOI
Specification and connectivity of neuronal subtypes in the sensory lineage
TL;DR: This review examines how neuronal diversity is created in the PNS and describes proteins that help to direct the diversity of neuronal subtypes, cell survival, axonal growth and the establishment of central patterns of modality-specific connections.
Journal ArticleDOI
Nrg1/ErbB signaling networks in Schwann cell development and myelination
TL;DR: Data that has defined the role of key Nrg1/ErbB signaling components like Shp2, ERK1/2, FAK, Rac1/Cdc42 and calcineurin in development of the Schwann cell lineage in vivo are reviewed.
Journal ArticleDOI
Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells
Jianqiang Wu,Jon P. Williams,Tilat A. Rizvi,Jennifer J. Kordich,David P. Witte,Dies Meijer,Anat Stemmer-Rachamimov,Jose A. Cancelas,Nancy Ratner +8 more
TL;DR: Peripheral nerve and tumors contain transiently proliferating Schwann cells that lose axonal contact, providing insight into early neurofibroma formation.
Journal ArticleDOI
Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression
TL;DR: Cal calcium imaging of acutely dissociated mouse sensory neurons and quantitative reverse transcription PCR are used to show that TRP cation channels emerge in waves, with the diversification of functional groups starting at embryonic day 12.5 (E12.5) and extending well into the postnatal life.
Journal ArticleDOI
Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells.
Hung-Chuan Pan,Fu-Chou Cheng,Chun-Jung Chen,Shu-Zhen Lai,Chi-Wen Lee,Dar-Yu Yang,Ming-Hong Chang,Shu-Peng Ho +7 more
TL;DR: Improved motor function recovery, the compound muscle action potential, and nerve conduction latency showed significant improvement in rats treated with amniotic fluid mesenchymal stem cells, which may facilitate regeneration in the sciatic nerve after crush injury.
References
More filters
Journal ArticleDOI
The origin and development of glial cells in peripheral nerves
Kristjan R. Jessen,Rhona Mirsky +1 more
TL;DR: Embryonic nerves offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves.
Journal ArticleDOI
Multiple essential functions of neuregulin in development
Dirk Meyer,Carmen Birchmeier +1 more
TL;DR: It is shown that neUREgulin -/ - embryos die during embryogenesis and display heart malformations, and the phenotype demonstrates that in vivo neuregulin acts locally and frequently in a paracrine manner.
Journal ArticleDOI
Axonal neuregulin-1 regulates myelin sheath thickness
Galin V. Michailov,Michael W. Sereda,Bastian G. Brinkmann,Tobias M. Fischer,Bernhard A. Haug,Carmen Birchmeier,Lorna W. Role,Cary Lai,Markus H. Schwab,Klaus-Armin Nave +9 more
TL;DR: This work uses mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells, and suggests a model by which myelin-forming SchwANN cells integrate axonal Nrg1 signals as a biochemical measure of axonsize.
Journal ArticleDOI
The transcription factor Sox10 is a key regulator of peripheral glial development
Stefan Britsch,Derk E. Goerich,Derk E. Goerich,Dieter Riethmacher,Reto I. Peirano,Reto I. Peirano,Moritz J. Rossner,Klaus-Armin Nave,Carmen Birchmeier,Michael Wegner,Michael Wegner +10 more
TL;DR: It is shown that the transcription factor Sox10 is a key regulator in differentiation of peripheral glial cells in mice that carry a spontaneous or a targeted mutation of Sox10, and that it controls expression of ErbB3 in neural crest cells.
Journal ArticleDOI
Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members
TL;DR: It is demonstrated that bone morphogenic protein 2 (BMP2) induces the basic-helix-loop- Helix protein MASH1 and neurogenesis in neural crest stem cells and some smooth muscle differentiation is also observed in BMP2.
Related Papers (5)
Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells.
The origin and development of glial cells in peripheral nerves
Kristjan R. Jessen,Rhona Mirsky +1 more