Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age.
Elena Rezus,Alexandra Burlui,Anca Cardoneanu,Ciprian Rezus,Catalin Codreanu,Mirela Pârvu,Gabriela Rusu Zota,Bogdan Ionel Tamba +7 more
TLDR
The relationship between old age and muscle wasting is discussed in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity.Abstract:
Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal muscle metabolic decline in the elderly has been gathering interest amongst researchers, as well as medical professionals, there are many challenges yet to be solved in order to counteract the effects of aging on muscle function efficiently. Noteworthy, it has been shown that aging individuals exhibit a decline in skeletal muscle metabolism, a phenomenon which may be linked to a number of predisposing (risk) factors such as telomere attrition, epigenetic changes, mitochondrial dysfunction, sedentary behavior (leading to body composition alterations), age-related low-grade systemic inflammation (inflammaging), hormonal imbalance, as well as a hypoproteic diet (unable to counterbalance the repercussions of the age-related increase in skeletal muscle catabolism). The present review aims to discuss the relationship between old age and muscle wasting in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity.read more
Citations
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Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss.
Richard Kirwan,Deaglan McCullough,Thomas Butler,Fátima Pérez de Heredia,Ian G Davies,Claire E. Stewart +5 more
TL;DR: In this paper, the authors review mechanisms of sarcopenia and their relation to the current data on the effects of COVID-19 confinement on physical activity, dietary habits, sleep, and stress as well as extended bed rest due to COVID19 hospitalization.
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The Link Between Inflammaging and Degenerative Joint Diseases.
Elena Rezuș,Anca Cardoneanu,Alexandra Burlui,Andrei Luca,Catalin Codreanu,Bogdan Ionel Tamba,Gabriela-Dumitrița Stanciu,Nicoleta Dima,Codruța Bădescu,Ciprian Rezuș +9 more
TL;DR: The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.
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Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
TL;DR: The role of myokines as potential biomarkers for the early diagnosis and therapeutic targets in SO are focused on.
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Dual-Task Exercise to Improve Cognition and Functional Capacity of Healthy Older Adults
Naina Yuki Vieira Jardim,Natáli Valim Oliver Bento-Torres,Victor Oliveira da Costa,Josilayne Patricia Ramos Carvalho,Helen Tatiane Santos Pontes,Alessandra Mendonça Tomás,Marcia Consentino Kronka Sosthenes,Kirk I. Erickson,João Bento-Torres,Cristovam Wanderley Picanço Diniz +9 more
TL;DR: In this paper, the effects of a dual-task multimodal physical exercise training, at moderate intensity, and cognitive stimulation on cognitive and physical function in healthy older adults were investigated.
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Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms
Jinkyung Cho,Youngju Choi,Pavol Sajgalik,Mi-Hyun No,Sanghyun Lee,Sujin Kim,Jun-Won Heo,Eun-Jeong Cho,Eunwook Chang,Ju-Hee Kang,Hyo-Bum Kwak,Dong-Ho Park +11 more
TL;DR: The pathophysiological mechanisms underlying sarc Openia in HF are reviewed as well as current knowledge regarding the beneficial effects of exercise on sarcopenia and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance are reviewed.
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