Inhibition of human immunodeficiency virus type-1 through autophagy.
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TLDR
This review summarizes recent advances in understanding the antiviral and replicative roles of autophagy during HIV infection andsecting the molecular mechanisms by which HIV utilizes autophagic may lead to the identification of novel drug candidates to treat and potentially eradicate HIV infection.About:
This article is published in Current Opinion in Microbiology.The article was published on 2013-06-01 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Autophagy & Acquired immune system.read more
Citations
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Journal ArticleDOI
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
TL;DR: The extraordinary dependence of HIV on human host proteins for efficient transmission and replication provides many new potential targets for antiretroviral therapy.
Journal ArticleDOI
TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress*
Nina Raben,Rosa Puertollano +1 more
TL;DR: The participation of the transcription factors TFEB and TFE3 in the regulation of lysosomal function and biogenesis, as well as the role of the lysOSomal pathway in cellular adaptation to a variety of stress conditions, are discussed.
Journal ArticleDOI
Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration
TL;DR: To the authors' knowledge, this is the first report of a virus modulating TFEB localization and helps to explain how HIV modulates autophagy to promote its own replication and cell survival.
Journal ArticleDOI
Emerging roles for TFEB in the immune response and inflammation.
TL;DR: The current state of knowledge linking TFEB and TFE3 to the processes of autophagy and inflammation is reviewed and several conditions, which are linked by these factors, are highlighted.
Journal ArticleDOI
Mitophagy in TGEV infection counteracts oxidative stress and apoptosis
TL;DR: It is reported that TGEV induces mitophagy to suppress oxidative stress and apoptosis induced by viral infection in porcine epithelial cells (IPEC-J2).
References
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Journal ArticleDOI
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
Journal ArticleDOI
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
Abraham L. Brass,Derek M. Dykxhoorn,Yair Benita,Nan Yan,Alan Engelman,Ramnik J. Xavier,Judy Lieberman,Stephen J. Elledge +7 more
TL;DR: This article performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs), which participate in a broad array of cellular functions and implicate new pathways in the viral life cycle.
Identification of host proteins required for HIV infection through a functional genomic screen
TL;DR: A large-scale small interfering RNA screen was performed to identify host factors required by HIV-1 and more than 250 HIV-dependency factors (HDFs) were identified, suggesting that viruses evolve in host cells that optimally perform the functions required for their life cycle.
Journal ArticleDOI
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams,Sovan Sarkar,Paul Cuddon,Evangelia K. Ttofi,Shinji Saiki,Farah H. Siddiqi,Luca Jahreiss,Angeleen Fleming,Dean Pask,Paul Goldsmith,Cahir J. O'Kane,R.A. Floto,David C. Rubinsztein +12 more
TL;DR: A cyclical mTOR-independent pathway regulating autophagy is revealed, in which cAMP regulates IP3 levels, influencing calpain activity, which completes the cycle by cleaving and activating G(s)alpha, which regulates cAMP levels.
Journal ArticleDOI
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin.
Jae-Min Yuk,Dong-Min Shin,Hye-Mi Lee,Chul-Su Yang,Hyo Sun Jin,Kwang-Kyu Kim,Zee-Won Lee,Sang-Hee Lee,Jin Man Kim,Eun-Kyeong Jo +9 more
TL;DR: It is shown that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophophagy-related genes Beclin-1 and Atg5.
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