Intake of a Single Morning Dose of Standard and Novel Plant Sterol Preparations for 4 Weeks Does Not Dramatically Affect Plasma Lipid Concentrations in Humans
Suhad S. AbuMweis,Catherine A. Vanstone,Naoyuki Ebine,Amira N. Kassis,Lynne M. Ausman,Peter B. Jones,Alice H. Lichtenstein +6 more
TLDR
Because standard forms of plant sterols did not reduce plasma cholesterol concentrations, the efficacy of the new formulation of Plant sterols cannot be confirmed from the present study design, where plant sterol were given as a single morning dose.Abstract:
Recommendations for decreasing the risk of developing cardiovascular disease include increasing the intake of plant sterols and fish oil. The cholesterol-lowering action of plant sterols, when provided in a fish-oil fatty acids vehicle, remains to be investigated in humans. A randomized, crossover-feeding, single-blind trial was conducted in 30 subjects with mild-to-moderate hypercholesterolemia to study the effects on plasma lipids of 2 novel forms of plant sterols: those combined with, or esterified to, fish-oil fatty acids. The treatments were margarine (control), free plant sterols, plant sterols esterified to fatty acids from sunflower oil, plant sterols esterified to very long-chained fatty acids from fish oil, and plant sterols combined with the same amount of very long-chained fatty acids from fish oil. Each sterol-containing food (1.0-1.8 g plant sterols/d) was consumed for 29 d as a single dose with breakfast under staff supervision. Compared with the control treatment, none of the plant sterol preparations reduced plasma total cholesterol or LDL cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, lipoprotein (a), or C-reactive protein concentration. Relative to the control phase, all plant sterols treatment increased the plasma HDL cholesterol concentration (P < 0.05) by approximately 8%. In conclusion, because standard forms of plant sterols did not reduce plasma cholesterol concentrations, the efficacy of the new formulation of plant sterols cannot be confirmed from the present study design, where plant sterols were given as a single morning dose.read more
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Continuous Dose-Response Relationship of the LDL-Cholesterol–Lowering Effect of Phytosterol Intake
Isabelle Demonty,R. T. Ras,H C M van der Knaap,Guus Duchateau,L. Meijer,Peter L. Zock,Johanna M. Geleijnse,Elke A. Trautwein +7 more
TL;DR: The dose-dependent LDL-C-lowering efficacy ofphytosterols incorporated in various food formats was confirmed and equations of the continuous relationship were established to predict the effect of a given phytosterol dose.
Continuous Dose-Response Relationship of the LDL-Cholesterol-Lowering Effect of
Isabelle Demonty,Rouyanne T. Ras,Henk C. M. van der Knaap,Peter L. Zock,Johanna M. Geleijnse,E.A. Trautwein +5 more
TL;DR: In this article, a meta-analysis of randomized controlled trials in adults was performed to establish a continuous dose-response relationship that would allow predicting the LDL-C-lowering efficacy of different phytosterol doses.
Journal ArticleDOI
Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials
TL;DR: Plant sterol containing products reduced LDL concentrations but the reduction was related to individuals’ baseline LDL levels, food carrier, and frequency and time of intake, and the observed differences between trial results were unlikely to have been caused by chance.
Journal ArticleDOI
Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses.
Robert A. Moreau,Laura Nyström,Bruce D. Whitaker,Jill K. Winkler-Moser,David J. Baer,Sarah K. Gebauer,Kevin B. Hicks +6 more
TL;DR: Phytosterol-enriched functional foods first appeared about twenty years ago and many clinical studies have confirmed the low density lipoprotein (LDL) cholesterol-lowering properties of various types of phytosterols, which have provided insights to better understand the cholesterol- Lowering and other biological effects of plant sterols.
Journal ArticleDOI
Phytosterols: physiologic and metabolic aspects related to cholesterol-lowering properties
TL;DR: Although some studies point to the possibility that elevated plasma phytosterol concentrations could contribute to the development of premature coronary artery diseases, extensive safety evaluation studies have been conducted for these compounds, and they have been considered safe.
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