Open Access
Intake of trans fatty acids and risk of coronary heart disease arnong wornen
Reads0
Chats0
TLDR
Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD, supporting the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence ofCHD.Abstract:
Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipopratein to highdensity-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids fram dietary questionnaires completed by 85 095 women without diagnosed CHD, strake, diabetes, or hypercholesteralaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1·50 [95% CI 1'12-2'00]. p for trend =:= 0·001). Additional control for established CH 0 risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol. vitamins Eor C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1'67 [1'05-2'66], p for trend =0'002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD.read more
Citations
More filters
Journal ArticleDOI
Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems
Walter C. Willett,Johan Rockström,Johan Rockström,Brent Loken,Marco Springmann,Tim Lang,Sonja J. Vermeulen,Sonja J. Vermeulen,Tara Garnett,David Tilman,David Tilman,Fabrice DeClerck,Fabrice DeClerck,Amanda Wood,Malin Jonell,Michael Clark,Line Gordon,Jessica Fanzo,Corinna Hawkes,Rami Zurayk,Juan A Rivera,Wim de Vries,Lindiwe Majele Sibanda,Ashkan Afshin,Abhishek Chaudhary,Abhishek Chaudhary,Mario Herrero,Rina Agustina,Francesco Branca,Anna Lartey,Shenggen Fan,Beatrice Crona,Elizabeth L. Fox,Victoria Bignet,Max Troell,Max Troell,Therese Lindahl,Therese Lindahl,Sudhvir Singh,Sarah Cornell,K. Srinath Reddy,Sunita Narain,Sania Nishtar,Christopher J L Murray +43 more
TL;DR: Food in the Anthropocene : the EAT-Lancet Commission on healthy diets from sustainable food systems focuses on meat, fish, vegetables and fruit as sources of protein.
Journal ArticleDOI
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
TL;DR: The effects of dietary fats on total:HDL cholesterol may differ markedly from their effects on LDL, and the effects of fats on these risk markers should not in themselves be considered to reflect changes in risk but should be confirmed by prospective observational studies or clinical trials.
Journal ArticleDOI
Primary prevention of coronary heart disease in women through diet and lifestyle.
TL;DR: Among women, adherence to lifestyle guidelines involving diet, exercise, and abstinence from smoking is associated with a very low risk of coronary heart disease.
Journal ArticleDOI
Dietary fat intake and the risk of coronary heart disease in women
Frank B. Hu,Meir J. Stampfer,JoAnn E. Manson,Eric B. Rimm,Graham A. Colditz,Bernard Rosner,Charles H. Hennekens,Walter C. Willett +7 more
TL;DR: It is suggested that replacing saturated and trans unsaturated fats with unhydrogenated monounsaturated and polyunsaturated fats is more effective in preventing coronary heart disease in women than reducing overall fat intake.
Journal ArticleDOI
Trans Fatty Acids and Cardiovascular Disease
TL;DR: The authors consider the feasibility and potential implications of reducing or eliminating the consumption of trans fatty acids from partially hydrogenated vegetable oils in the United States.
References
More filters
Journal ArticleDOI
Reproducibility and validity of a semiquantitative food frequency questionnaire
Walter C. Willett,Walter C. Willett,Laura Sampson,Meir J. Stampfer,Meir J. Stampfer,Bernard Rosner,Chris Bain,Jelia C. Witschi,Charles H. Hennekens,Frank E. Speizer +9 more
TL;DR: Data indicate that a simple self-administered dietary questionnaire can provide useful information about individual nutrient intakes over a one-year period.
Journal ArticleDOI
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.
Meir J. Stampfer,Graham A. Colditz,Walter C. Willett,JoAnn E. Manson,Bernard Rosner,Frank E. Speizer,Charles H. Hennekens +6 more
TL;DR: Current estrogen use is associated with a reduction in the incidence of coronary heart disease as well as in mortality from cardiovascular disease, but it is not associated with any change in the risk of stroke.
Journal ArticleDOI
Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects.
TL;DR: The effect of trans fatty acids on the serum lipoprotein profile is at least as unfavorable as that of the cholesterol-raising saturated fatty acids, because they not only raise LDL cholesterol levels but also lower HDL cholesterol levels.
Journal ArticleDOI
Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women.
TL;DR: These prospective data provide evidence for the hypothesis that a high intake of animal fat increases the risk of colon cancer, and they support existing recommendations to substitute fish and chicken for meats high in fat.