Journal ArticleDOI
Integrin diversity brings specificity in mechanotransduction.
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TLDR
How the expression of particular integrin subtypes affects cellular adaptation to substrate rigidity is described and the role of integrins and associated proteins in mechanotransduction is explained, focusing on their specificity in mechanosensing and force transmission.About:
This article is published in Biology of the Cell.The article was published on 2018-03-01. It has received 77 citations till now. The article focuses on the topics: Mechanotransduction & Integrin.read more
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Integrins as biomechanical sensors of the microenvironment.
TL;DR: An overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering is provided, and how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals.
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Cellular mechanotransduction: From tension to function
TL;DR: A critical review of the recent insights into the molecular basis of cellular mechanotransduction is provided, by analyzing how mechanical stimuli get transformed into a given biological response through the activation of a peculiar genetic program.
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Biological responses to physicochemical properties of biomaterial surface.
TL;DR: This review addresses both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry and aims to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses.
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The extracellular matrix in development.
TL;DR: Current understanding of how the extracellular matrix helps guide developing tissues by influencing cell adhesion, migration, shape and differentiation is discussed, emphasizing the biophysical cues it provides.
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Integrins, CAFs and Mechanical Forces in the Progression of Cancer.
Imjoo Jang,Karen A. Beningo +1 more
TL;DR: The role of integrins, as the primary cell-ECM mechanoreceptors, in cancer progression is discussed, highlighting integrin-mediated mechanical communication between cancer cells and CAFs.
References
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Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Integrins: Bidirectional, Allosteric Signaling Machines
TL;DR: Current structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways.
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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Anne J. Ridley,Alan Hall +1 more
TL;DR: Rho, a ras-related GTP-binding protein, rapidly stimulated stress fiber and focal adhesion formation when microinjected into serum-starved Swiss 3T3 cells, implying that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors.
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Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
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The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.