Journal ArticleDOI
Interaction network linking the human H3N2 influenza A virus genomic RNA segments.
Emilie Fournier,Vincent Moules,Boris Essere,Jean-Christophe Paillart,Jean-Daniel Sirbat,Annie Cavalier,Jean-Paul Rolland,Daniel Thomas,Bruno Lina,Catherine Isel,Roland Marquet +10 more
TLDR
Support is provided for the involvement of RNA/RNA interactions in the selection and specific packaging of influenza A genomic RNAs, which appear embedded into an organised supramolecular complex likely held together by direct base-pairings between packaging signals.About:
This article is published in Vaccine.The article was published on 2012-12-07. It has received 82 citations till now. The article focuses on the topics: Influenza A virus & RNA.read more
Citations
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At the centre: influenza A virus ribonucleoproteins
TL;DR: This Review discusses current knowledge about vRNP trafficking within host cells and the function of these complexes in the context of the virus life cycle, highlighting how structure contributes to function and the crucial interactions with host cell pathways, as well as on the information gaps that remain.
Journal ArticleDOI
Reassortment in segmented RNA viruses: mechanisms and outcomes.
TL;DR: Recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families are discussed and how these findings provide new perspectives on the replication and evolution of segmented RNA viruses are discussed.
Journal ArticleDOI
Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis.
TL;DR: It is found that upon infection, the viral RNAs from the incoming particles travel together until they reach the nucleus, and this newly characterized step of the genome packaging process demonstrates the precise spatiotemporal regulation of the infection cycle.
Journal ArticleDOI
Selective packaging of the influenza A genome and consequences for genetic reassortment
TL;DR: Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics help to understand the rules that govern genome packaging, and have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.
Journal ArticleDOI
Influenza a virus assembly intermediates fuse in the cytoplasm.
Seema S. Lakdawala,Yicong Wu,Peter Wawrzusin,Juraj Kabat,Andrew J. Broadbent,Elaine W. Lamirande,Ervin Fodor,Nihal Altan-Bonnet,Hari Shroff,Kanta Subbarao +9 more
TL;DR: The data strongly support a model in which vRNA segments are exported from the nucleus as complexes that assemble en route to the plasma membrane through dynamic colocalization events in the cytoplasm.
References
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Emergence and pandemic potential of swine-origin H1N1 influenza virus.
TL;DR: Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.
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Influenza: lessons from past pandemics, warnings from current incidents
TL;DR: A review of molecular factors that contribute to the emergence of pandemic strains in poultry and in humans and the eradication of pathogenic avian influenza viruses is reviewed.
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The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication
Agustín Portela,Paul Digard +1 more
TL;DR: The purpose of this review is to illustrate using the influenza virus NP as a well-studied example that the molecule is much more than a structural RNA-binding protein, but also functions as a key adapter molecule between virus and host cell processes.
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Influenza virus pleiomorphy characterized by cryoelectron tomography.
Audray K. Harris,Giovanni Cardone,Dennis C. Winkler,J. Bernard Heymann,Matthew Brecher,Judith M. White,Alasdair C. Steven +6 more
TL;DR: Cryoelectron tomography is used to visualize the 3D structures of 110 individual virions of the X-31 (H3N2) strain of influenza A, and some virions have substantial gaps in their matrix layer, and others appear to lack a matrix layer entirely, suggesting the existence of an alternative budding pathway in which matrix protein is minimally involved.