Journal ArticleDOI
Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1α and MMP-9.
Reads0
Chats0
TLDR
IL-17 synergizes with CoCl2 induced hypoxic condition to augment osteoclast mediated bone erosion and synovial macrophages mediated RA pathogenesis.About:
This article is published in Cellular Immunology.The article was published on 2018-10-01. It has received 19 citations till now. The article focuses on the topics: Osteoclast & RANKL.read more
Citations
More filters
Journal ArticleDOI
Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update.
Noushin Lotfi,Rodolfo Thomé,Nahid Rezaei,Guang-Xian Zhang,Abbas Rezaei,Abdolmohamad Rostami,Nafiseh Esmaeil +6 more
TL;DR: This review aimed for a comprehensive analysis of literature data on the multiple roles of GM-CSF in autoimmue diseases and possible therapeutic strategies that target GM- CSF production.
Journal ArticleDOI
IL-17A and IL-17F orchestrate macrophages to promote lung cancer
TL;DR: The data indicate that IL-17A/F act through immune cell orchestration, i.e., of macrophages, to promote lung cancer cell growth and progression through an increased migration capacity in vitro and enhanced in vivo tumor growth, proliferation and angiogenesis.
Journal ArticleDOI
Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes
TL;DR: It is shown that anti-GM-CSF treatment induces modulatory monocytes that act in a CXCL-11-dependent manner, a mechanism that can be used in the development of novel approaches to treat chronic inflammatory autoimmune diseases.
Journal ArticleDOI
Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis.
TL;DR: This study provides the first evidence that cyanidin can be used as IL-17/17RA signalling targeting therapeutic drug for the treatment of RA and this need to be investigated in RA patients.
Journal ArticleDOI
Expression of lactate dehydrogenase is induced during hypoxia via HIF-1 in the mud crab Scylla paramamosain.
Jia-Wei Xie,Changhong Cheng,Yu-Kun Jie,Hongling Ma,Juan Feng,Youlu Su,Yiqin Deng,Haidong Xu,Guo Zhixun,Guo Zhixun +9 more
TL;DR: The results indicated that SpLDH expression was regulated transcriptionally by HIF-1, which blocked the increase in LDH mRNA and activity, which were induced by hypoxia in gill and muscle tissues.
References
More filters
Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
The pathogenesis of rheumatoid arthritis.
Iain B. McInnes,Georg Schett +1 more
TL;DR: The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
Journal ArticleDOI
Bone Resorption by Osteoclasts
TL;DR: Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone.
Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
Hypoxia and Inflammation
TL;DR: This review deals with emerging evidence of an association between systemic or local hypoxia and inflammation in a variety of diseases and points to new ways of treating inflammatory disorders or conditions such as certain cancers with intralesional Hypoxia.