Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy.
TLDR
A role for IL-6 is unveiled in hypertrophic muscle growth and mechanistic evidence for the contribution of satellite cells to this process is provided and a role for STAT3 activation and expression is revealed in a paracrine fashion.About:
This article is published in Cell Metabolism.The article was published on 2008-01-01 and is currently open access. It has received 734 citations till now. The article focuses on the topics: Myocyte & Muscle hypertrophy.read more
Citations
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Muscles, exercise and obesity: skeletal muscle as a secretory organ
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.
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Satellite Cells and the Muscle Stem Cell Niche
TL;DR: For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.
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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Aaron W. Joe,Lin Yi,Anuradha Natarajan,Fabien Le Grand,Leslie So,Joy X. Wang,Michael A. Rudnicki,Fabio M.V. Rossi +7 more
TL;DR: A new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage is described, which expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progensitors.
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Mechanisms regulating skeletal muscle growth and atrophy
TL;DR: Two major protein degradation pathways, the proteasomal and the autophagic–lysosomal pathways, are activated during muscle atrophy and variably contribute to the loss of muscle mass.
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Regulatory interactions between muscle and the immune system during muscle regeneration
TL;DR: Evidence that indicates that the response of myeloid cells to muscle injury promotes muscle regeneration and growth is evaluated, showing that transitions in macrophage phenotype are an essential component of muscle regeneration in vivo following acute or chronic muscle damage.
References
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Sue C. Bodine,Trevor Stitt,Michael Gonzalez,William O. Kline,Gretchen L. Stover,Roy Bauerlein,Elizabeth Zlotchenko,Angus Scrimgeour,John C. Lawrence,David J. Glass,George D. Yancopoulos +10 more
TL;DR: It is concluded that the activation of the Akt/mTOR pathway and its downstream targets, p70S6K and PHAS-1/4E-BP1, is requisitely involved in regulating skeletal muscle fibre size, and that activation of this pathway can oppose muscle atrophy induced by disuse.
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Impaired immune and acute-phase responses in interleukin-6-deficient mice
Manfred Kopf,Heinz Baumann,Giulia Freer,Marina A. Freudenberg,Marinus C. Lamers,Tadamitsu Kishimoto,Rolf M. Zinkernagel,Horst Bluethmann,Georges Köhler +8 more
TL;DR: It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TL;DR: It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
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Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
Orna Halevy,Bennett G. Novitch,Douglas B. Spicer,Stephen X. Skapek,James Rhee,Gregory J. Hannon,David Beach,Andrew B. Lassar +7 more
TL;DR: MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21, a skeletal muscle-specific transcriptional regulator, during differentiation of murine myocytes and in nonmyogenic cells.
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Skeletal muscle hypertrophy and atrophy signaling pathways.
TL;DR: Recent progress in the understanding of molecular signalling, which governs skeletal muscle atrophy and hypertrophy, and the known instances of cross-regulation between the two systems are focused on.