Journal ArticleDOI
Intermediate filaments: structure, dynamics, function, and disease.
Elaine Fuchs,Klaus Weber +1 more
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This article is published in Annual Review of Biochemistry.The article was published on 1994-01-01. It has received 1447 citations till now. The article focuses on the topics: Protein structure function & Intermediate Filament Protein.read more
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Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin
TL;DR: It is indicated that multiple integral membrane proteins with four putative transmembrane domains, occludin and claudins, constitute TJ strands.
Journal ArticleDOI
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
TL;DR: Molecular connections between integrins, cytoskeletal filaments, and nuclear scaffolds may provide a discrete path for mechanical signal transfer through cells as well as a mechanism for producing integrated changes in cell and nuclear structure in response to changes in extracellular matrix adhesivity or mechanics.
Journal ArticleDOI
The cornified envelope: a model of cell death in the skin
TL;DR: New insights into the molecular mechanisms and the physiological endpoints of cornification are increasing the understanding of the pathological defects of this unique form of programmed cell death, which is associated with barrier malfunctions and ichthyosis.
Journal ArticleDOI
Biomechanics and biophysics of cancer cells.
TL;DR: It is reasoned through experimental evidence that greater understanding of the mechanics of cancer cell deformability and its interactions with the extracellular physical, chemical and biological environments offers enormous potential for significant new developments in disease diagnostics, prophylactics, therapeutics and drug efficacy assays.
Journal ArticleDOI
Vimentin in cancer and its potential as a molecular target for cancer therapy.
Arun Satelli,Shulin Li +1 more
TL;DR: By virtue of its overexpression in cancer and its association with tumor growth and metastasis, vimentin serves as an attractive potential target for cancer therapy; however, more research would be crucial to evaluate its specific role in cancer.
Related Papers (5)
A Structural Scaffolding of Intermediate Filaments in Health and Disease
Elaine Fuchs,Don W. Cleveland +1 more