Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
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TLDR
The role of mitochondria in the delayed outcomes of ionization radiation is discussed, and different types of radiation vary in their linear energy transfer (LET) properties, and their effects on various aspects of mitochondrial physiology are discussed.About:
This article is published in Cancer Letters.The article was published on 2012-12-31 and is currently open access. It has received 1013 citations till now. The article focuses on the topics: Oxidative stress & DNA damage.read more
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Radiobiology for the Radiologist
TL;DR: This text is a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA.
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Glutathione: new roles in redox signaling for an old antioxidant
TL;DR: This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
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Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.
TL;DR: Chemical mechanisms for IR-induced modifications of biomolecules along with methods for their detection are described and the synergy of combined "omics" technologies such as genomics and epigenomics, proteomics, and metabolomics is highlighted.
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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.
Guang Lei,Guang Lei,Yilei Zhang,Pranavi Koppula,Xiaoguang Liu,Jie Zhang,Steven H. Lin,Steven H. Lin,Jaffer A. Ajani,Qin Xiao,Zhongxing Liao,Hui Wang,Boyi Gan +12 more
TL;DR: This study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted.
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Effects of ionizing radiation on mitochondria
TL;DR: In this article, the authors discuss experimental observations of the effects of ionizing radiation on the mitochondria at (1) the DNA and (2) functional levels, and discuss the roles of mitochondria in (3) oxidative stress and (4) late radiation effects.
References
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Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
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Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
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Free Radicals in the Physiological Control of Cell Function
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Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.