Journal ArticleDOI
Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
TLDR
The cytotoxic effect of juglone can be attributed to mechanisms including the induction of oxidative stress, cell membrane damage, and a clastogenic action leading to cell death by both apoptosis and necrosis.About:
This article is published in Cell Biology International.The article was published on 2009-10-01. It has received 140 citations till now. The article focuses on the topics: Juglone & Genotoxicity.read more
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Pro-Oxidant Natural Products as Anticancer Agents
Carmen Martín-Cordero,Antonio J. León-González,José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Miguel López-Lázaro +4 more
TL;DR: An overview of natural products with pro-oxidant and anticancer activities, with special focus on plant secondary metabolites, and discusses their possible use as cancer chemotherapeutic agents.
Journal ArticleDOI
HPLC Determination of Phenolic Acids, Flavonoids and Juglone in Walnut Leaves
TL;DR: High concentrations of myricetin, catechin hydrate and rutin, and low concentrations of quercetin and epicatechin aglycones were revealed in walnut leaves samples from nine different cultivars with the same agricultural, geographical and climatic conditions.
Journal ArticleDOI
Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants.
Joshua R. Widhalm,David Rhodes +1 more
TL;DR: In this review, the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.
Journal ArticleDOI
A Comparative Review on the Extraction, Antioxidant Content and Antioxidant Potential of Different Parts of Walnut (Juglans regia L.) Fruit and Tree.
TL;DR: The antioxidant content of phenolic extracts obtained from different parts of the walnut tree and fruit are described to describe the antioxidant and antiradical activities of the prepared extracts.
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Quinones derived from plant secondary metabolites as anti-cancer agents
TL;DR: This review focuses on the anti- cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone, and intends to summarize their anti-cancer effects and investigate the mechanism of actions.
References
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed and has been used to analyze experimental data obtained from enzymatic, cellular and animal systems.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.