Journal ArticleDOI
Laboratory-based surveillance of Clostridium difficile strains circulating in the Australian healthcare setting in 2012
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TLDR
While no RTs were associated with CA-CDI, RTs 056 and 126 were recently found in Australian production animals, indicating a possible community health threat in Australia.About:
This article is published in Pathology.The article was published on 2017-04-01. It has received 23 citations till now. The article focuses on the topics: Clostridium difficile.read more
Citations
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Genome analysis of Clostridium difficile PCR ribotype 014 lineage in australian pigs and humans reveals a diverse genetic repertoire and signatures of long-range interspecies transmission
Daniel R. Knight,Michele M. Squire,Deirdre A. Collins,Deirdre A. Collins,Thomas V. Riley,Thomas V. Riley +5 more
TL;DR: Novel insights are provided on the genetic variability and strain relatedness of C. difficile RT014, a lineage of emerging One Health importance and the first pan-genome analysis for this lineage, characterizing its resistome, prophage content, and in silico virulence potential.
Journal ArticleDOI
Clostridium difficile and One Health.
TL;DR: Evidence is presented that demonstrates transmission of C. difficile in hospitals from asymptomatic carriers to symptomatic CDI patients, and an interconnected transmission pathway for C.difficile involving food animals, humans and the environment is presented.
Journal ArticleDOI
Genomic Delineation of Zoonotic Origins of Clostridium difficile.
Daniel R. Knight,Thomas V. Riley +1 more
TL;DR: Evolution, and zoonotic aspects of CDI are discussed, including the anthropomorphic factors that contribute to the spread of C. difficile from the farm to the community, and findings indicate either a zoonosis or anthroponosis.
Journal ArticleDOI
Clostridium difficile ribotype 017 - characterization, evolution and epidemiology of the dominant strain in Asia.
Korakrit Imwattana,Daniel R. Knight,Brian Kullin,Deirdre A. Collins,Papanin Putsathit,Pattarachai Kiratisin,Thomas V. Riley +6 more
TL;DR: An important feature of C. difficile RT 017 strains is their resistance to several antimicrobials and this has been documented as a possible factor driving multiple outbreaks in different parts of the world.
Journal ArticleDOI
Clostridium difficile colitis and zoonotic origins-a narrative review
TL;DR: The epidemiological differences between hospital- and community- acquired CDI are discussed, including some emerging evidence for community-acquired CDI being a possible zoonosis.
References
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Journal ArticleDOI
An epidemic, toxin gene-variant strain of Clostridium difficile.
L. Clifford McDonald,George Killgore,Angela Thompson,Robert C. Owens,Sophia Kazakova,Susan P. Sambol,Stuart Johnson,Dale N. Gerding +7 more
TL;DR: A previously uncommon strain of C. difficile with variations in toxin genes has become more resistant to fluoroquinolones and has emerged as a cause of geographically dispersed outbreaks of C.'s Difficile-associated disease.
Journal ArticleDOI
Clostridium difficile infection in Europe: a hospital-based survey
Martijn P. Bauer,Daan W. Notermans,Birgit H. B. van Benthem,Jon S. Brazier,Mark H. Wilcox,Maja Rupnik,Dominique L Monnet,Jaap T. van Dissel,Ed J. Kuijper +8 more
TL;DR: The data emphasise the importance of multicountry surveillance to detect and control C difficile infection in Europe and build capacity for diagnosis and surveillance.
Journal ArticleDOI
The Changing Epidemiology of Clostridium difficile Infections
Jane Freeman,Martijn P. Bauer,Simon D. Baines,Jeroen Corver,Warren N. Fawley,B. Goorhuis,Ed J. Kuijper,Mark H. Wilcox +7 more
TL;DR: The evidence for the changing epidemiology, clinical virulence and outcome of treatment of CDI is reviewed, and the similarities and differences between data from various countries and continents are reviewed.
Journal ArticleDOI
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Miao He,Fabio Miyajima,Paul Roberts,Louise Ellison,Derek Pickard,Melissa J. Martin,Thomas R. Connor,Simon R. Harris,Derek Fairley,Kathleen B. Bamford,Kathleen B. Bamford,Stephanie d’Arc,Stephanie d’Arc,Jon S. Brazier,Derek J. Brown,J. E. Coia,Gill Douce,Dale N. Gerding,Heejung Kim,Tse Hsien Koh,Haru Kato,Mitsutoshi Senoh,Tom Louie,Stephen L. Michell,Emma Butt,Sharon J. Peacock,Nicholas M. Brown,Nicholas M. Brown,Thomas V. Riley,Glen Songer,Mark H. Wilcox,Munir Pirmohamed,Ed J. Kuijper,Peter M. Hawkey,Brendan W. Wren,Gordon Dougan,Julian Parkhill,Trevor D. Lawley +37 more
TL;DR: This analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.
Journal ArticleDOI
Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
David W Eyre,Madeleine Cule,Daniel J. Wilson,David J. Griffiths,Alison Vaughan,Lily O’Connor,Ip Clc.,Tanya Golubchik,Elizabeth M. Batty,John Finney,David H. Wyllie,Xavier Didelot,Paolo Piazza,Rory Bowden,Kate E. Dingle,Rosalind M. Harding,Derrick W. Crook,Mark H. Wilcox,Peto Tea.,AS Walker +19 more
TL;DR: Genetically diverse sources, in addition to symptomatic patients, play a major part in C. difficile transmission, which suggests a considerable reservoir of C. Difficile infection identified in health care settings or in the community in Oxfordshire.
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Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Miao He,Fabio Miyajima,Paul Roberts,Louise Ellison,Derek Pickard,Melissa J. Martin,Thomas R. Connor,Simon R. Harris,Derek Fairley,Kathleen B. Bamford,Kathleen B. Bamford,Stephanie d’Arc,Stephanie d’Arc,Jon S. Brazier,Derek J. Brown,J. E. Coia,Gill Douce,Dale N. Gerding,Heejung Kim,Tse Hsien Koh,Haru Kato,Mitsutoshi Senoh,Tom Louie,Stephen L. Michell,Emma Butt,Sharon J. Peacock,Nicholas M. Brown,Nicholas M. Brown,Thomas V. Riley,Glen Songer,Mark H. Wilcox,Munir Pirmohamed,Ed J. Kuijper,Peter M. Hawkey,Brendan W. Wren,Gordon Dougan,Julian Parkhill,Trevor D. Lawley +37 more