Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression
TLDR
In this article , the authors reviewed the well-known sex difference in incidence of major depressive disorder, with women being twice as likely to be diagnosed as men, and briefly summarized how the impact of MDD varies between men and women, with sex differences in symptoms, severity, and antidepressant drug response.About:
This article is published in Biological Psychiatry.The article was published on 2022-01-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Major depressive disorder & Sex characteristics.read more
Citations
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Stress induced microglial activation contributes to depression.
TL;DR: In this paper , the authors discuss candidate mechanisms by which stress induces microglia to deviate from its fine-tuned homeostasis in clinical and preclinical studies, which may contribute to the pathogenesis of depressive disorder.
Journal ArticleDOI
The neuropeptide landscape of human prefrontal cortex
Wen Zhong,Swapnali Barde,Nicholas Mitsios,Csaba Ádori,Per Oksvold,Kalle von Feilitzen,Liam Anuj O’Leary,László Csiba,Tibor Hortobágyi,Péter Szocsics,Naguib Mechawar,Zsófia Maglóczky,Éva Renner,Miklós Palkovits,Mathias Uhlén,Jan Mulder,Tomas Hökfelt +16 more
TL;DR: The results suggest that the well-established anatomical and functional heterogeneity of human PFC is also reflected in the expression pattern of the neuropeptides.
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Beyond the neuron: Role of non-neuronal cells in stress disorders
Flurin Cathomas,Leanne M. Holt,Eric M. Parise,Jian Liu,James W. Murrough,Patrizia Casaccia,Eric J. Nestler,Scott J. Russo +7 more
TL;DR: In this paper , the authors synthesize emerging literature and discuss mechanisms of how non-neuronal cells in limbic regions of brain interface at synapses, the neurovascular unit, and other sites of intercellular communication to mediate the deleterious, or adaptive (i.e., proresilient), effects of chronic stress in rodent models and in human stress-related disorders.
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Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited
TL;DR: This paper provided an overview of the relationships between baseline and depression/stress-related transcriptional sex differences and explore contributions of preclinically identified mechanisms and their impacts on behavior. But, their approach must become more systemic and less reductionist, as we move forward from accepting the existence of extensive molecular sex differences in the brain to exploring the purpose of these sex differences.
Journal ArticleDOI
Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited
TL;DR: In this article , the authors provide an overview of the relationships between baseline and depression/stress-related transcriptional sex differences and explore contributions of preclinically identified mechanisms and their impacts on behavior.
References
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TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
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