Journal ArticleDOI
Leukemia and brain tumors among children after radiation exposure from CT scans : design and methodological opportunities of the Dutch Pediatric CT Study
Johanna M. Meulepas,Cécile M. Ronckers,Anne M. J. B. Smets,Rutger A.J. Nievelstein,Andreas Jahnen,Choonsik Lee,Mariette Kieft,Johan S. Laméris,Marcel van Herk,Marcel J. W. Greuter,Cécile R. L. P. N. Jeukens,Marcel van Straten,Otto Visser,Flora E. van Leeuwen,Michael Hauptmann +14 more
TLDR
The proposed approaches provide useful strategies for data collection and confounder assessment for general retrospective record-linkage studies, particular those using hospital databases on radiological procedures for the assessment of exposure to ionizing or non-ionizing radiation.Abstract:
Computed tomography (CT) scans are indispensable in modern medicine; however, the spectacular rise in global use coupled with relatively high doses of ionizing radiation per examination have raised radiation protection concerns. Children are of particular concern because they are more sensitive to radiation-induced cancer compared with adults and have a long lifespan to express harmful effects which may offset clinical benefits of performing a scan. This paper describes the design and methodology of a nationwide study, the Dutch Pediatric CT Study, regarding risk of leukemia and brain tumors in children after radiation exposure from CT scans. It is a retrospective record-linkage cohort study with an expected number of 100,000 children who received at least one electronically archived CT scan covering the calendar period since the introduction of digital archiving until 2012. Information on all archived CT scans of these children will be obtained, including date of examination, scanned body part and radiologist's report, as well as the machine settings required for organ dose estimation. We will obtain cancer incidence by record linkage with external databases. In this article, we describe several approaches to the collection of data on archived CT scans, the estimation of radiation doses and the assessment of confounding. The proposed approaches provide useful strategies for data collection and confounder assessment for general retrospective record-linkage studies, particular those using hospital databases on radiological procedures for the assessment of exposure to ionizing or non-ionizing radiation.read more
Citations
More filters
Journal ArticleDOI
Sparse-sampling computed tomography for detection of endoleak after endovascular aortic repair (EVAR).
Felix Meurer,Felix K. Kopp,Martin Renz,Felix N. Harder,Yannik Leonhardt,Rolf Bippus,Peter B. Noël,M Makowski,Andreas Sauter +8 more
TL;DR: In this article, the authors evaluated sparse sampling computed tomography (SpSCT) for detection of endoleak after endovascular aortic repair (EVAR) at different dose levels in terms of subjective image criteria and diagnostic accuracy.
Journal ArticleDOI
Cumulative diagnostic imaging radiation exposure in premature neonates.
TL;DR: In this article, the cumulative effective ionizing radiation dose (cED) in microSieverts (μSv) received by premature infants ≤32 weeks from diagnostic studies performed throughout their NICU stay, and predictors of exposures.
Journal ArticleDOI
Re: "Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands".
Surgical Management of Craniosynostosis
TL;DR: Performing aggressive cranial or cranio-orbital remodeling provides the best cosmetic results, it should better be performed after sixth month of age to reduce any anticipated morbidity and not be delayed beyond the first year of life if a good cosmetic outcome is desired.
Book ChapterDOI
Radiation Safety in Patients
TL;DR: This chapter addresses questions and gives insight in the risk of ionizing radiation in molecular imaging techniques and how the protocols on the hybrid systems be optimized so that the patient gets the optimal imaging with a dose as low as reasonably achievable.
References
More filters
Journal ArticleDOI
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study
Mark S. Pearce,J Salotti,Mark P. Little,Kieran McHugh,Choonsik Lee,Kwang Pyo Kim,Nicola Howe,Cécile M. Ronckers,Preetha Rajaraman,Alan W. Craft,Louise Parker,Amy Berrington de Gonzalez +11 more
TL;DR: Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses ofabout 60 m Gy might triple therisk of brain cancer.
Journal ArticleDOI
Estimated Risks of Radiation-Induced Fatal Cancer from Pediatric CT
TL;DR: It is suggested that pediatric CT will result in significantly increased lifetime radiation risk over adult CT, both because of the increased dose per milliampere-second, and the increased lifetime risk per unit dose.
Journal ArticleDOI
Projected cancer risks from computed tomographic scans performed in the United States in 2007.
Amy Berrington de Gonzalez,Mahadevappa Mahesh,Kwang Pyo Kim,Mythreyi Bhargavan,Mythreyi Bhargavan,Rebecca S. Lewis,Fred A. Mettler,Charles E. Land +7 more
TL;DR: These detailed estimates highlight several areas of CT scan use that make large contributions to the total cancer risk, including several scan types and age groups with a high frequency of use or scans involving relatively high doses, in which risk-reduction efforts may be warranted.
Journal ArticleDOI
Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians
John D. Mathews,Anna V. Forsythe,Zoe Brady,Martin W Butler,Stacy Goergen,Graham Byrnes,Graham G. Giles,Anthony Wallace,Philip R Anderson,Philip R Anderson,Tenniel Guiver,Paul McGale,Timothy M. Cain,James G. Dowty,Adrian Bickerstaffe,Sarah C. Darby +15 more
TL;DR: The increased incidence of cancer after CT scan exposure in this cohort was mostly due to irradiation, and future CT scans should be limited to situations where there is a definite clinical indication, with every scan optimised to provide a diagnostic CT image at the lowest possible radiation dose.