Journal ArticleDOI
Life and death in peripheral T cells
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TLDR
The concepts of activation-induced cell death (AICD) and activated cell-autonomous death (ACAD) in the regulation of life and death in T cells are discussed.Abstract:
During the course of an immune response, antigen-reactive T cells clonally expand and then are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is determined by multiple factors, such as T-cell receptor triggering, co-stimulation or cytokine signalling, and by molecules, such as caspase-8 (FLICE)-like inhibitory protein (FLIP) and haematopoietic progenitor kinase 1 (HPK1), which regulate the nuclear factor-kappaB (NF-kappaB) pathway. Here, we discuss the concepts of activation-induced cell death (AICD) and activated cell-autonomous death (ACAD) in the regulation of life and death in T cells.read more
Citations
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Expression of the memory marker CD45RO on helper T cells in macaques.
Michael Valentine,Michael Valentine,Kejing Song,Grace A. Maresh,Heather Mack,Maria Cecilia Huaman,Patricia Polacino,On Ho,Anthony D. Cristillo,Hye Kyung Chung,Shiu Lok Hu,Seth H. Pincus,Seth H. Pincus +12 more
TL;DR: CD45RO, defined with mAb UCHL1, is well expressed on CD4+ cells in pigtailed macaques, and may define the cellular locus of the reservoir of HIV.
Journal ArticleDOI
Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells
TL;DR: There is a baseline intracellular expression of the complement C3, C5, C3aR and C5aR1 genes in normal CD4+ T cells, but that expression is not increased during T-cell activation, but rather down regulated.
Journal ArticleDOI
SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice
Tone Berge,Ingrid Helene Bø Grønningsæter,Kristina Berg Lorvik,Greger Abrahamsen,Stine Granum,Vibeke Sundvold-Gjerstad,Alexandre Corthay,Bjarne Bogen,Anne Spurkland +8 more
TL;DR: Results suggest a modulatory role for SH2D2A in T cell mediated immune surveillance of cancer, however, it remains to be established whether its effect is T-cell intrinsic.
Journal Article
Role of apoptosis-inducing factor (Aif) in the T cell lineage
Savit Prabhu,Jasneet Kaur Khalsa,Hridesh Banerjee,Abhishek Das,Smita Srivastava,Hamid Mattoo,Krishnamurthy Thyagarajan,Shalini Tanwar,Deepika Sharma Das,Subeer S. Majumdar,Anna George,Vineeta Bal,Jeannine M. Durdik,Satyajit Rath +13 more
TL;DR: Findings generate the possibility of specific T cell dysfunction in human disease caused by Aif deficiency, as well as in mitochondriopathies due to other causes, and raise questions regarding the basis of lineage-specific consequences of the dysfunction/deficiency of apparently ubiquitous molecules.
Journal ArticleDOI
Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4+ T cells and is regulated by Fas/FasL signaling
Gorjana Rackov,Parinaz Tavakoli Zaniani,Sara Colomo del Pino,Rahman Shokri,Jorge Monserrat,Melchor Alvarez-Mon,Carlos Martínez-A,Dimitrios Balomenos +7 more
TL;DR: In this paper , the authors found that mROS are required for IL-12 plus IL-18-driven production of IFN-γ, an essential cytokine for inflammatory and autoimmune disease development.
References
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Journal ArticleDOI
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