Lipid and Carbohydrate Metabolism in Caenorhabditis Elegans
Jennifer L. Watts,Michael Ristow +1 more
TLDR
This review outlines lipid and carbohydrate structures as well as biosynthesis and breakdown pathways that have been characterized in C. elegans and brings attention to functional studies using mutant strains that reveal physiological roles for specific lipids and carbohydrates during development, aging, and adaptation to changing environmental conditions.Abstract:
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior. In this review, we outline lipid and carbohydrate structures as well as biosynthesis and breakdown pathways that have been characterized in C. elegans We bring attention to functional studies using mutant strains that reveal physiological roles for specific lipids and carbohydrates during development, aging, and adaptation to changing environmental conditions.read more
Citations
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TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging.
TL;DR: The state of the TOR field in C. elegans is reviewed, and what is learned about its functions in development, metabolism, and aging is focused on.
Journal ArticleDOI
WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data
Amy D. Holdorf,Daniel P Higgins,Anne C. Hart,Peter R. Boag,Gregory J. Pazour,Albertha J.M. Walhout,Amy K. Walker +6 more
TL;DR: WormCat, a web-based tool that uses a near-complete annotation of the C. elegans genome to identify coexpressed gene sets and scaled heat map for enrichment visualization, is developed and tested, showing that it reproduces major categories identified by GO.
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Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?
TL;DR: Evidence is discussed from C. elegans and murine/human systems supporting the concept of an ancestral principle regulating innate immune memory by controlling cellular metabolism, posit that changes in cellular metabolism may be a common denominator of innateimmune memory from lower animals to mammals.
Journal ArticleDOI
Biology of the Caenorhabditis elegans Germline Stem Cell System.
TL;DR: C. elegans is a powerful model for understanding germline stem cells and stem cell biology and the Notch regulated genetic network that controls the key decision between the stem cell fate and meiotic development occurs under optimal laboratory conditions in adult and larval stages.
Journal ArticleDOI
Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism.
Stefan Zdraljevic,Bennett W. Fox,Christine Strand,Oishika Panda,Oishika Panda,Francisco J Tenjo,Shannon C. Brady,Timothy A. Crombie,John G. Doench,Frank C. Schroeder,Erik C. Andersen +10 more
TL;DR: This study implicates the BCKDH complex and BCAA metabolism in arsenic responses, demonstrating the power of C. elegans natural genetic diversity to identify novel mechanisms by which environmental toxins affect organismal physiology.
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