Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection
Shuyi Wu,Jianmeng Xu,Leiyan Zou,Shulu Luo,Run Yao,Bingna Zheng,Guo-bin Liang,Dingcai Wu,Yan Li +8 more
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TLDR
Wang et al. as mentioned in this paper reported an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility.Abstract:
Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection.read more
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References
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TL;DR: Advances in scientific knowledge on structural molecules, proteins, teichoic acids, and the most recently described extracellular DNA, on the synthesis and genetics of staphylococcal biofilms, and on the complex network of signal factors that intervene in their control are presented are presented, also reporting on the emerging strategies to disrupt or inhibit them.
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Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis
TL;DR: It is evident that periodontitis and peri-implantitis are not fundamentally different from the perspectives of etiology, pathogenesis, risk assessment, diagnosis and therapy, Nevertheless, some difference in the host response to these two infections may explain the occasional rapid progression of pero-IMplantitis lesions.
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Balancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces.
TL;DR: Advances in this field will require concurrent development in surface modification techniques and a better understanding of the complex and highly inter-related events occurring at the implant surface after implantation.