Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Book ChapterDOI
Lipid Carriers: Role and Applications in Nano Drug Delivery
Naveen Chella,Nalini R. Shastri +1 more
TL;DR: This chapter focuses on different lipid-based carrier systems, their role in nano delivery and the advantages offered in improvement of solubility, absorption, and bioavailability with relevant case studies.
Journal ArticleDOI
Nanocapsules embedded in microparticles for enhanced oral bioavailability and efficacy of Lopinavir as an anti-AIDS drug.
Taher Nassar,Ayala Rohald,Natalya Naraykin,Dinorah Barasch,Orit Amsalem,Ponnandy Prabhu,Moshe Kotler,Simon Benita +7 more
TL;DR: Results obtained from rat studies showed a two-fold higher bioavailability of LPV following oral administration of the optimal formulation than Kaletra®, the marketed drug, showing that when properly entrapped, LPV can be effectively protected from CYP degradation in the gut as well as from the liver following systemic absorption.
Journal ArticleDOI
Preparation and characterization of Biochanin A loaded solid lipid nanoparticles
TL;DR: In this paper, a Biochanin A (BCA) loaded solid lipid nanoparticles (SLN) was used to improve solution and prolong the half-life of BCA.
Journal ArticleDOI
Solid lipid nanoparticles for targeted natural and synthetic drugs delivery in high-incidence cancers, and other diseases: Roles of preparation methods, lipid composition, transitional stability, and release profiles in nanocarriers’ development
Hamdoon A. Mohammed,Riaz A. Khan,Varsha Singh,Md. Yusuf,Naseem Akhtar,Ghassan M. Sulaiman,Salim Albukhaty,Ahmed A. H. Abdellatif,Maria Khan,Salman A. A. Mohammed,Amal Al-Subaiyel +10 more
TL;DR: Solid lipid nanoparticles (SLNs) as mentioned in this paper have been developed as promising nanocarriers for different high-incidence cancers and other disease therapies, including the Alzheimer's, Parkinson's, and tuberculosis.
References
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Book ChapterDOI
Stability Testing of New Drug Substances and Products
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more