Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Nano-ART and NeuroAIDS
TL;DR: This review focuses on how nanotechnology can serve to improve the delivery of antiretroviral medicines, termed NanoART, across the blood–brain barrier and affect the biodistribution and clinical benefit for NeuroAIDS.
Journal ArticleDOI
Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology
TL;DR: Two-factor three level factorial design was considered for optimization of formulations of erythromycin solid lipid nanocarriers and showed that the optimal ERY-SLN was composed of lipid concentration 15 mg/mL and surfactant : cosurfactant ratio 1 : 1 with %EE of 88.40 ± 2.09%.
Journal ArticleDOI
Microwave-assisted microemulsion technique for production of miconazole nitrate- and econazole nitrate-loaded solid lipid nanoparticles.
TL;DR: Encouraging results suggest that the microwave‐assisted procedure is suitable for encapsulation of ionic drugs and that microwave‐produced SLNs can act as potential carriers of antifungal drugs.
Journal ArticleDOI
Effect of particle size on oral bioavailability of Darunavir loaded solid lipid nanoparticles.
Jagruti Desai,Hetal Thakkar +1 more
TL;DR: The in vivo pharmacokinetics in rats showed a significant increase in oral bioavailability of darunavir from all the three formulations in comparison to plain drug suspension and reference tablet and the results revealed insignificant difference between SLNs of 100 and 200 nm.
Journal ArticleDOI
Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles
Ander Estella-Hermoso de Mendoza,Miguel Angel Campanero,Hugo Lana,Janny A. Villa-Pulgarin,Janis de la Iglesia-Vicente,Faustino Mollinedo,María J. Blanco-Prieto +6 more
TL;DR: Edelfosine-loaded LNs showed a high accumulation of the drug in lymph nodes and resulted in slower tumor growth than the free drug in a murine lymphoma xenograft model, as well as potent extranodal dissemination inhibition.
References
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Book ChapterDOI
Stability Testing of New Drug Substances and Products
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more