Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.
Journal ArticleDOI
Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.
Journal ArticleDOI
Solid lipid nanoparticles: an oral bioavailability enhancer vehicle.
TL;DR: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT, and make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
Journal ArticleDOI
Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery
TL;DR: This review highlights the simple and easily scaled-up novel SLN and NLC along with their different production techniques, hurdles, and strategies for the production of LNs, characterization, lyophilization and drug release and summarizes the research findings reported by the different researchers regarding the different method of preparation, excipients and their significant findings.
Journal ArticleDOI
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Yongtao Duan,Abhishek Dhar,Chetan K. Patel,Mehul Khimani,Swarnali Neogi,Prolay Sharma,Nadavala Siva Kumar,Rohit L. Vekariya +7 more
TL;DR: Although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
References
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Journal ArticleDOI
Oral bioavailability of cyclosporine: Solid lipid nanoparticles (SLN®) versus drug nanocrystals
Rainer H. Müller,Stephan Anton Runge,V. Ravelli,W. Mehnert,Andreas F. Thünemann,Eliana B. Souto +5 more
TL;DR: In this study it has been proved that using SLN as a drug carrier for oral administration of cyclosporine A a low variation in bioavailability of the drug and simultaneously avoiding the plasma peak typical of the first Sandimmun formulation can be achieved.
Journal ArticleDOI
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs.
Lian-Dong Hu,Xing Tang,Fu-De Cui +2 more
TL;DR: Results indicate that ATRA absorption is enhanced significantly by employing SLN formulations, and SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs.
Journal ArticleDOI
Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery.
Rishi Paliwal,Shivani Rai,Bhuvaneshwar Vaidya,Kapil Khatri,Amit K. Goyal,Neeraj Mishra,Abhinav Mehta,Suresh P. Vyas +7 more
TL;DR: The comparative study conducted on methotrexate (MTX)-bearing SLNs revealed that the formulation based on Compritol 888 ATO could noticeably improve the oral bioavailability of MTX, presumably following SLNs constituting lipid digestion and co-absorption through lymphatic transport and route.
Journal ArticleDOI
Cyclosporine-loaded solid lipid nanoparticles (SLN®): Drug–lipid physicochemical interactions and characterization of drug incorporation
Rainer H. Müller,Stephan Anton Runge,V. Ravelli,Andreas F. Thünemann,W. Mehnert,Eliana B. Souto,Eliana B. Souto +6 more
TL;DR: It could be concluded that cyclosporine is molecularly dispersed in between the fatty acid chains of the liquid-crystalline alpha-modification fraction of the loaded SLN.
Journal ArticleDOI
Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
Monica Macal,Sumathi Sankaran,Chun Tw,Elizabeth Reay,Jason Flamm,Prindiville Tj,Satya Dandekar +6 more
TL;DR: It is suggested that a threshold of>50% CD4+ T-cell restoration may be sufficient for polyfunctional HIV-specific T cells with implications in the evaluation of vaccines and therapeutics.
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