Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Development of Lipid Polymer Hybrid Drug Delivery Systems Prepared by Hot-Melt Extrusion
Gleidson Cardoso,Ludmila A.G. Pinho,Felipe T. Martins,Marcilio Cunha-Filho,Stephânia Fleury Taveira,Ricardo Neves Marreto +5 more
TL;DR: In this paper , the authors developed polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME), and the lipid and polymeric adjuvants were selected based on miscibility and compatibility studies.
Journal ArticleDOI
Compritol: A Versatile Excipient for Novel Drug Delivery System
TL;DR: The potential pharmaceutical, as well as cosmeceuticals applicability of compritol as a novel excipient has been highlighted and its utility in the pharmaceutical and cosMEceutical industries is discussed.
References
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Book ChapterDOI
Stability Testing of New Drug Substances and Products
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
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W. Mehnert,Karsten Mäder +1 more