Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Encapsulation of ritonavir in solid lipid nanoparticles: in-vitro anti-HIV-1 activity using lentiviral particles
TL;DR: In this study, ritonavir was entrapped into solid lipid nanoparticles (SLNs) employing two production methods and antiretroviral activity was investigated for more efficient formulation.
Journal ArticleDOI
Freeze-Dried Lopinavir-Loaded Nanostructured Lipid Carriers for Enhanced Cellular Uptake and Bioavailability: Statistical Optimization, in Vitro and in Vivo Evaluations.
Arshad Ali Khan,Arshad Ali Khan,Jahanzeb Mudassir,Jahanzeb Mudassir,Safia Akhtar,Safia Akhtar,Vikneswaran Murugaiyah,Yusrida Darwis +7 more
TL;DR: The nanostructured lipid carriers are potential carriers for improving the oral bioavailability of lopinavir and shown a spherical shape by transmission and scanning electron microscopes.
Journal ArticleDOI
Praziquantel-Solid Lipid Nanoparticles Produced by Supercritical Carbon Dioxide Extraction: Physicochemical Characterization, Release Profile, and Cytotoxicity.
Luciana Nalone Andrade,Daniele M. L. Oliveira,Marco Vinícius Chaud,Thais Francine Ribeiro Alves,Marcelo Nery,Classius Ferreira da Silva,Joyce Kelly Marinheiro da Cunha Gonsalves,Rogéria De Souza Nunes,Cristiane Bani Corrêa,Ricardo Guimarães Amaral,Elena Sánchez-López,Eliana B. Souto,Patrícia Severino +12 more
TL;DR: This study demonstrates that SCF may be a suitable scale-up procedure for the production of SLN, which have shown to be an appropriate carrier for PZQ.
Journal ArticleDOI
Cytotoxicity of solid lipid nanoparticles and nanostructured lipid carriers containing the local anesthetic dibucaine designed for topical application
Raquel de Melo Barbosa,C. M. G. da Silva,T. S. Bella,Daniele Ribeiro de Araujo,Priscyla D. Marcato,Nelson Durán,Nelson Durán,E. de Paula +7 more
TL;DR: Evaluating the cytotoxic activity of DBC-loaded SLN and NLC against 3T3 fibroblast and HaCat keratinocyte cells indicated the potential of these nanocarriers for clinical applications.
Journal ArticleDOI
Enhancement of In Vivo Efficacy and Oral Bioavailability of Aripiprazole with Solid Lipid Nanoparticles.
Silki,Vivek Ranjan Sinha +1 more
TL;DR: Solid lipid nanoparticles can improve the bioavailability of lipophilic drugs like aripiprazole by enhancement of absorption and minimizing first-pass metabolism.
References
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Book ChapterDOI
Stability Testing of New Drug Substances and Products
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
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