Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Book ChapterDOI
Infectious Diseases: Need for Targeted Drug Delivery
TL;DR: Application of targeted delivery in the treatment of veterinary infections is exemplified and future possibilities indicated, stressing on the promise of targeted drug delivery in augmenting therapy of infectious diseases.
Journal ArticleDOI
Targeted solid lipid nanoparticles with peptide ligand for oral delivery of atorvastatin calcium
TL;DR: It is demonstrated that CSK-modified SLNs could be potential carriers for the transport of drugs across intestinal barriers by coupling the peptide ligand CSKSSDYQC to stearic acid.
Journal ArticleDOI
Lung cancer targeting efficiency of Silibinin loaded Poly Caprolactone /Pluronic F68 Inhalable nanoparticles: In vitro and In vivo study
TL;DR: Findings indicate that SB-loaded PCL/Pluronic F 68 nanoparticles may be a successful lung cancer therapy delivery system and significantly inhibited tumour growth in lung cancer-induced rats after inhalable administration.
Journal ArticleDOI
Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.
TL;DR: In this paper, the nano-reformulation of the repurposed drugs for inhalation is proposed as a promising approach for targeted drug delivery to lungs, which can provide a stronger, more localized action, with reduced adverse effects.
Journal ArticleDOI
Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles.
Limei Han,Limei Han,Qiushi Yang,Qiushi Yang,Teng Shen,Teng Shen,Jin Qing,Jin Qing,Jianxin Wang,Jianxin Wang +9 more
TL;DR: It is suggested that mPEG-DSPE micellar formulation could provide a useful alternative approach for improving the lymphatic transport of hydrophobic compounds.
References
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Book ChapterDOI
Stability Testing of New Drug Substances and Products
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
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