Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.
Journal ArticleDOI
Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.
Journal ArticleDOI
Solid lipid nanoparticles: an oral bioavailability enhancer vehicle.
TL;DR: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT, and make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
Journal ArticleDOI
Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery
TL;DR: This review highlights the simple and easily scaled-up novel SLN and NLC along with their different production techniques, hurdles, and strategies for the production of LNs, characterization, lyophilization and drug release and summarizes the research findings reported by the different researchers regarding the different method of preparation, excipients and their significant findings.
Journal ArticleDOI
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Yongtao Duan,Abhishek Dhar,Chetan K. Patel,Mehul Khimani,Swarnali Neogi,Prolay Sharma,Nadavala Siva Kumar,Rohit L. Vekariya +7 more
TL;DR: Although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
References
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Journal ArticleDOI
A bioequivalence study comparing two formulations of lopinavir/ritonavir capsules.
Tippabhotla Sk,N R Thudi,R Raghuvanshi,Arshad Khuroo,S. Gurule,S Mishra,Tausif Monif,V K C Lao +7 more
TL;DR: It was found that the test/reference (T/R) ratios for the pharmacokinetic parameters AUC (0-t), AUC(0-infinity) and C(max) were well within the bioequivalence acceptance range of 80-125% as per international regulatory guidelines.
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