Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TLDR
From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).Citations
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Journal ArticleDOI
Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.
Journal ArticleDOI
Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.
Journal ArticleDOI
Solid lipid nanoparticles: an oral bioavailability enhancer vehicle.
TL;DR: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT, and make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
Journal ArticleDOI
Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery
TL;DR: This review highlights the simple and easily scaled-up novel SLN and NLC along with their different production techniques, hurdles, and strategies for the production of LNs, characterization, lyophilization and drug release and summarizes the research findings reported by the different researchers regarding the different method of preparation, excipients and their significant findings.
Journal ArticleDOI
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Yongtao Duan,Abhishek Dhar,Chetan K. Patel,Mehul Khimani,Swarnali Neogi,Prolay Sharma,Nadavala Siva Kumar,Rohit L. Vekariya +7 more
TL;DR: Although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
References
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Journal ArticleDOI
Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice
Matthieu Prot,Laurence Heripret,Laurence Heripret,Nathalie Cardot-Leccia,Christophe Perrin,Myriam Aouadi,Myriam Aouadi,Thibaud Lavrut,Rodolphe Garraffo,Pierre Dellamonica,Jacques Durant,Yannick Le Marchand-Brustel,Yannick Le Marchand-Brustel,Bernard Binétruy +13 more
TL;DR: The results demonstrate that the long-term treatment of mice with PIs constitutes an interesting experimental model with which some aspects of the lipoatrophy induced by HAART in humans may be studied.
Journal ArticleDOI
Development and validation of dissolution test for lopinavir, a poorly water-soluble drug, in soft gel capsules, based on in vivo data.
TL;DR: Both the HPLC method and the in vitro dissolution method were validated and could be used to evaluate the release profile of lopinavir soft gel capsules and showed accuracy, precision, linearity and specificity within the acceptable range.
Book ChapterDOI
Solid lipid nanoparticles and microemulsions for drug delivery The CNS.
TL;DR: Evidence that the many important pharmacokinetic parameters were notably improved versus the drug alone or in a commercial formulation is put in evidence.
Journal ArticleDOI
Preparation and performance evaluation of saquinavir laden cationic submicron emulsions.
TL;DR: It can be concluded that induction of positive charge on submicron emulsions can be effective for improving oral absorption of drug safely, as it is evinced with low LDH release into the medium when intestinal tissue is treated with submicrons emulsion.
Journal ArticleDOI
An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat
TL;DR: A comparison of the relative enhancement of lymphatic transport and plasma bioavailability compared to control reveals a greater effect of verapamil and ketoconazole on the amount of drug transported by the lymphatic route, an observation consistent with a preferential targeting of saquinavir via the intestinal lymphatics.
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W. Mehnert,Karsten Mäder +1 more